Oral microbiota related to allergy in Norwegian adults
Background: Oral microbiome composition has been linked to onset and progression of several localized and systemic diseases. Associations with allergy in adults have been less explored. Objective: We sought to identify oral microbiota associated with allergy outcomes in adults using high-throughput...
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Elsevier
2025-05-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325000360 |
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| author | Mikyeong Lee, PhD Hilde Kristin Vindenes, MD, PhD Farnaz Fouladi, PhD Rajesh Shigdel, PhD James M. Ward, MSc Shayamal D. Peddada, PhD Stephanie J. London, MD, DrPH Randi Jacobsen Bertelsen, PhD |
| author_facet | Mikyeong Lee, PhD Hilde Kristin Vindenes, MD, PhD Farnaz Fouladi, PhD Rajesh Shigdel, PhD James M. Ward, MSc Shayamal D. Peddada, PhD Stephanie J. London, MD, DrPH Randi Jacobsen Bertelsen, PhD |
| author_sort | Mikyeong Lee, PhD |
| collection | DOAJ |
| description | Background: Oral microbiome composition has been linked to onset and progression of several localized and systemic diseases. Associations with allergy in adults have been less explored. Objective: We sought to identify oral microbiota associated with allergy outcomes in adults using high-throughput sequencing data. Methods: We characterized bacterial communities of gingival samples from 453 Norwegian adults (average age, 28 years) using 16S rRNA gene amplicon sequencing. We examined more than 2200 bacterial taxa in relation to self-reported current asthma, eczema, or rhinitis, and seroatopy (IgE > 0.70 kU/L). We used linear regression to determine whether overall bacterial diversity differed by each allergic outcome and analysis of composition of microbiomes with bias correction (ANCOM-BC2) to identify differentially abundant taxa. Results: Less diverse oral bacterial communities were observed (P < .05) in individuals with atopy or rhinitis compared with those without. Bacterial diversity did not differ by asthma and eczema status. While no bacterial taxa were differentially abundant by asthma, many were differentially abundant (P < .05 after multiple-testing correction) in relation to atopy, eczema, and rhinitis. These taxa include several from the genera Leptotrichia and Fusobacterium. Some, including Streptococcus, were previously implicated in respiratory health, whereas others were novel. We also found taxa related to nasal medication use in individuals with rhinitis. Notably, microbial network interconnections differed by allergy status. Conclusions: Bacterial community compositions of oral gingival samples may play a role in allergic outcomes in adults. These findings could contribute to the development of novel treatment strategies. |
| format | Article |
| id | doaj-art-b2ed16deccae4af0b7f1ff100ffdda27 |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-b2ed16deccae4af0b7f1ff100ffdda272025-08-20T03:49:03ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-05-014210043510.1016/j.jacig.2025.100435Oral microbiota related to allergy in Norwegian adultsMikyeong Lee, PhD0Hilde Kristin Vindenes, MD, PhD1Farnaz Fouladi, PhD2Rajesh Shigdel, PhD3James M. Ward, MSc4Shayamal D. Peddada, PhD5Stephanie J. London, MD, DrPH6Randi Jacobsen Bertelsen, PhD7Immunity Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC; Corresponding author: Mikyeong Lee, PhD, Immunity Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr, PO Box 12233, MD A3-03, Research Triangle Park, NC 27709.Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, NorwayBiostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NCDepartment of Clinical Science, University of Bergen, Bergen, NorwayIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NCBiostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NCImmunity Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NCDepartment of Clinical Science, University of Bergen, Bergen, Norway; Oral Health Centre of Expertise in Western Norway–Vestland, Bergen, NorwayBackground: Oral microbiome composition has been linked to onset and progression of several localized and systemic diseases. Associations with allergy in adults have been less explored. Objective: We sought to identify oral microbiota associated with allergy outcomes in adults using high-throughput sequencing data. Methods: We characterized bacterial communities of gingival samples from 453 Norwegian adults (average age, 28 years) using 16S rRNA gene amplicon sequencing. We examined more than 2200 bacterial taxa in relation to self-reported current asthma, eczema, or rhinitis, and seroatopy (IgE > 0.70 kU/L). We used linear regression to determine whether overall bacterial diversity differed by each allergic outcome and analysis of composition of microbiomes with bias correction (ANCOM-BC2) to identify differentially abundant taxa. Results: Less diverse oral bacterial communities were observed (P < .05) in individuals with atopy or rhinitis compared with those without. Bacterial diversity did not differ by asthma and eczema status. While no bacterial taxa were differentially abundant by asthma, many were differentially abundant (P < .05 after multiple-testing correction) in relation to atopy, eczema, and rhinitis. These taxa include several from the genera Leptotrichia and Fusobacterium. Some, including Streptococcus, were previously implicated in respiratory health, whereas others were novel. We also found taxa related to nasal medication use in individuals with rhinitis. Notably, microbial network interconnections differed by allergy status. Conclusions: Bacterial community compositions of oral gingival samples may play a role in allergic outcomes in adults. These findings could contribute to the development of novel treatment strategies.http://www.sciencedirect.com/science/article/pii/S2772829325000360Bacteriaallergy and immunologyhost microbial interactionsmicrobiomedysbiosis |
| spellingShingle | Mikyeong Lee, PhD Hilde Kristin Vindenes, MD, PhD Farnaz Fouladi, PhD Rajesh Shigdel, PhD James M. Ward, MSc Shayamal D. Peddada, PhD Stephanie J. London, MD, DrPH Randi Jacobsen Bertelsen, PhD Oral microbiota related to allergy in Norwegian adults Journal of Allergy and Clinical Immunology: Global Bacteria allergy and immunology host microbial interactions microbiome dysbiosis |
| title | Oral microbiota related to allergy in Norwegian adults |
| title_full | Oral microbiota related to allergy in Norwegian adults |
| title_fullStr | Oral microbiota related to allergy in Norwegian adults |
| title_full_unstemmed | Oral microbiota related to allergy in Norwegian adults |
| title_short | Oral microbiota related to allergy in Norwegian adults |
| title_sort | oral microbiota related to allergy in norwegian adults |
| topic | Bacteria allergy and immunology host microbial interactions microbiome dysbiosis |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000360 |
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