Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia
Dengue infection has been associated with oxidative stress (OS) induction; however, whether such a response predicts the development of complications remains unknown. We conducted a case-control study (1:2 ratio) nested within a cohort of febrile patients with a presumptive or confirmed diagnosis of...
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2025-01-01
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| author | Anyela Lozano-Parra Víctor Herrera Luis Ángel Villar |
| author_facet | Anyela Lozano-Parra Víctor Herrera Luis Ángel Villar |
| author_sort | Anyela Lozano-Parra |
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| description | Dengue infection has been associated with oxidative stress (OS) induction; however, whether such a response predicts the development of complications remains unknown. We conducted a case-control study (1:2 ratio) nested within a cohort of febrile patients with a presumptive or confirmed diagnosis of dengue. Incident cases were patients who developed hypotension or severe bleeding during the follow-up, whereas controls did not. Total antioxidant status (TAS), superoxide dismutase (SOD), and glutathione peroxidase activity (GPx) were quantified in serums obtained ≤96 h from disease onset. The association between each biomarker and complications was evaluated by estimating adjusted odds ratios (ORs) using logistic regression. We evaluated 132 patients (median age: 19.0 years; 58.2% males). TAS and SOD were higher among cases than controls (2.1 versus 1.7 mM and 6.7 versus 6.0 U/mL, respectively), and the opposite was observed for GPx (128.1 versus 133.7 mmol/min/mL); however, none of these contrasts reached statistical significance. In the multivariate analysis, higher levels of TAS and SOD were associated with a higher likelihood of complications up to 3.5 mM (OR = 2.46; 95%CI: 1.10–5.53) and 8.0 U/mL (OR = 1.69; 95%CI: 1.01–2.83), respectively. GPx did not show an association with hypotension or severe bleeding. Our results suggest that the induction of OS during the acute phase of dengue infection might be a prognostic factor of hypotensive and hemorrhagic complications. |
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| institution | Kabale University |
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| spelling | doaj-art-b2eab8354b45467991f2760f483c745f2025-01-24T13:51:23ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-01-011011410.3390/tropicalmed10010014Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in ColombiaAnyela Lozano-Parra0Víctor Herrera1Luis Ángel Villar2Grupo de Epidemiología Clínica, Escuela de Medicina, Universidad Industrial de Santander UIS, Calle 9 Carrera 27, Bucaramanga 680002, ColombiaGrupo de Epidemiología Clínica, Escuela de Medicina, Universidad Industrial de Santander UIS, Calle 9 Carrera 27, Bucaramanga 680002, ColombiaCentro de Atención y Diagnóstico de Enfermedades Infecciosas (CDI), Fundación INFOVIDA, Cra. 37 No. 51-126, Bucaramanga 680003, ColombiaDengue infection has been associated with oxidative stress (OS) induction; however, whether such a response predicts the development of complications remains unknown. We conducted a case-control study (1:2 ratio) nested within a cohort of febrile patients with a presumptive or confirmed diagnosis of dengue. Incident cases were patients who developed hypotension or severe bleeding during the follow-up, whereas controls did not. Total antioxidant status (TAS), superoxide dismutase (SOD), and glutathione peroxidase activity (GPx) were quantified in serums obtained ≤96 h from disease onset. The association between each biomarker and complications was evaluated by estimating adjusted odds ratios (ORs) using logistic regression. We evaluated 132 patients (median age: 19.0 years; 58.2% males). TAS and SOD were higher among cases than controls (2.1 versus 1.7 mM and 6.7 versus 6.0 U/mL, respectively), and the opposite was observed for GPx (128.1 versus 133.7 mmol/min/mL); however, none of these contrasts reached statistical significance. In the multivariate analysis, higher levels of TAS and SOD were associated with a higher likelihood of complications up to 3.5 mM (OR = 2.46; 95%CI: 1.10–5.53) and 8.0 U/mL (OR = 1.69; 95%CI: 1.01–2.83), respectively. GPx did not show an association with hypotension or severe bleeding. Our results suggest that the induction of OS during the acute phase of dengue infection might be a prognostic factor of hypotensive and hemorrhagic complications.https://www.mdpi.com/2414-6366/10/1/14severe dengueoxidative stressglutathione peroxidasesuperoxide dismutasetotal antioxidant status |
| spellingShingle | Anyela Lozano-Parra Víctor Herrera Luis Ángel Villar Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia Tropical Medicine and Infectious Disease severe dengue oxidative stress glutathione peroxidase superoxide dismutase total antioxidant status |
| title | Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia |
| title_full | Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia |
| title_fullStr | Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia |
| title_full_unstemmed | Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia |
| title_short | Antioxidant Response as a Candidate Prognostic Factor for Dengue Hypotensive and Hemorrhagic Complications: Results from a Nested Case-Control Study in Colombia |
| title_sort | antioxidant response as a candidate prognostic factor for dengue hypotensive and hemorrhagic complications results from a nested case control study in colombia |
| topic | severe dengue oxidative stress glutathione peroxidase superoxide dismutase total antioxidant status |
| url | https://www.mdpi.com/2414-6366/10/1/14 |
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