Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo
Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable. We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autolog...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/532139 |
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| author | Pedro Redondo Ana Giménez de Azcarate Laura Marqués María García-Guzman Enrique Andreu Felipe Prósper |
| author_facet | Pedro Redondo Ana Giménez de Azcarate Laura Marqués María García-Guzman Enrique Andreu Felipe Prósper |
| author_sort | Pedro Redondo |
| collection | DOAJ |
| description | Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable. We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autologous melanocytes' culture on a denuded amniotic membrane (AM). A culture biopsy was obtained in every patient and grown in melanocytes' media for 10–14 days after which cells were transferred to a denuded AM and transplanted into the achromic lesions. Patients were followed for up to 6 months using clinical assessment of achromic lesions. Treated areas ranged between 4 cm2 and 210.6 cm2. Response to treatment was excellent in all patients with 90–95% repigmentation success rate. Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo. |
| format | Article |
| id | doaj-art-b2e640ef1d0f4de48d11b46367895255 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-b2e640ef1d0f4de48d11b463678952552025-08-20T03:39:21ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/532139532139Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable VitiligoPedro Redondo0Ana Giménez de Azcarate1Laura Marqués2María García-Guzman3Enrique Andreu4Felipe Prósper5Department of Dermatology, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainDepartment of Dermatology, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainDepartment of Dermatology, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainArea of Cell Therapy, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainArea of Cell Therapy, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainArea of Cell Therapy, University Clinic of Navarra, University of Navarra, 31008 Pamplona, SpainVitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable. We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autologous melanocytes' culture on a denuded amniotic membrane (AM). A culture biopsy was obtained in every patient and grown in melanocytes' media for 10–14 days after which cells were transferred to a denuded AM and transplanted into the achromic lesions. Patients were followed for up to 6 months using clinical assessment of achromic lesions. Treated areas ranged between 4 cm2 and 210.6 cm2. Response to treatment was excellent in all patients with 90–95% repigmentation success rate. Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo.http://dx.doi.org/10.1155/2011/532139 |
| spellingShingle | Pedro Redondo Ana Giménez de Azcarate Laura Marqués María García-Guzman Enrique Andreu Felipe Prósper Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo Dermatology Research and Practice |
| title | Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo |
| title_full | Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo |
| title_fullStr | Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo |
| title_full_unstemmed | Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo |
| title_short | Amniotic Membrane as a Scaffold for Melanocyte Transplantation in Patients with Stable Vitiligo |
| title_sort | amniotic membrane as a scaffold for melanocyte transplantation in patients with stable vitiligo |
| url | http://dx.doi.org/10.1155/2011/532139 |
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