Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions
Relevance. COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency of studies evaluating factors leading to infection among COVID-19 vaccinated individuals.Aim. Identification of epidemiological features that distinguish cases of the disease in va...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2024-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/1913 |
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| author | M. P. Kostinov Chen Zhang I. A. Khrapunova A. S. Pechenik V. A. Brazhnik V. A. Utkin M. N. Laktionova A. V. Linok S. P. Raicic |
| author_facet | M. P. Kostinov Chen Zhang I. A. Khrapunova A. S. Pechenik V. A. Brazhnik V. A. Utkin M. N. Laktionova A. V. Linok S. P. Raicic |
| author_sort | M. P. Kostinov |
| collection | DOAJ |
| description | Relevance. COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency of studies evaluating factors leading to infection among COVID-19 vaccinated individuals.Aim. Identification of epidemiological features that distinguish cases of the disease in vaccinated and unvaccinated cohorts.Materials and methods. The analysis of the incidence of COVID-19 in 1126 hospitalized patients in the period from 23.06.2021 to 01.05.2022 was carried out taking into account the presence or absence of vaccination against the SARS-CoV-2 virus.Results. It was found that the risk of COVID-19 getting sick in the unimmunized was 1.5 times higher than in the vaccinated (p < 0.05). The incidence of hospitalization, due to the severity of the condition (moderate, severe and extremely severe), in unvaccinated people with no history of comorbidities, is more than 3 times higher than in vaccinated people (p < 0.05) in the same group. The probability of death from COVID-19 among vaccinated people is 1.5 times lower than among unimmunized people (p < 0.05). The age characteristic of mortality in vaccinated people shifts to the «senile» age (76.93 ± 1.32), while among the unimmunized, the age of death is closer to the category of «elderly» (73.74 ± 1.39 years) (p ≤ 0.05). In the structure of mortality among the vaccinated, the main share was made up of patients with a history of 3 to 7 concomitant systemic diseases (66.7%), while among the unvaccinated, the main share (74.5%) were patients either without comorbidities or with a history of 1 to 2 concomitant diseases.Conclusion. The results of the epidemiological features of the COVID-2 epidemic process have shown that vaccination against the SARS-CoV-2 virus is vital for elderly and senile people with comorbid conditions. |
| format | Article |
| id | doaj-art-b2e3936fbd894451ba605586c8ef9706 |
| institution | DOAJ |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Numikom LLC |
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| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-b2e3936fbd894451ba605586c8ef97062025-08-20T03:01:34ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942024-01-0122613313810.31631/2073-3046-2023-22-6-133-138997Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid ConditionsM. P. Kostinov0Chen Zhang1I. A. Khrapunova2A. S. Pechenik3V. A. Brazhnik4V. A. Utkin5M. N. Laktionova6A. V. Linok7S. P. Raicic8Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Federal State Budgetary Scientific Institution «Research Institute of Vaccines and Serums them. I.I. Mechnikov»Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Central Research Institute of Epidemiology of RospotrebnadzorCity Clinical Hospital No. 29 of the Moscow City Health DepartmentCity Clinical Hospital No. 29 of the Moscow City Health DepartmentCenter for Biomedical Technologies of the North Caucasus Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of RussiaFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Federal State Budgetary Scientific Institution «Research Institute of Vaccines and Serums them. I.I. Mechnikov»Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Relevance. COVID-19 vaccination reduces mortality and the course of severe diseases. However, there is an insufficiency of studies evaluating factors leading to infection among COVID-19 vaccinated individuals.Aim. Identification of epidemiological features that distinguish cases of the disease in vaccinated and unvaccinated cohorts.Materials and methods. The analysis of the incidence of COVID-19 in 1126 hospitalized patients in the period from 23.06.2021 to 01.05.2022 was carried out taking into account the presence or absence of vaccination against the SARS-CoV-2 virus.Results. It was found that the risk of COVID-19 getting sick in the unimmunized was 1.5 times higher than in the vaccinated (p < 0.05). The incidence of hospitalization, due to the severity of the condition (moderate, severe and extremely severe), in unvaccinated people with no history of comorbidities, is more than 3 times higher than in vaccinated people (p < 0.05) in the same group. The probability of death from COVID-19 among vaccinated people is 1.5 times lower than among unimmunized people (p < 0.05). The age characteristic of mortality in vaccinated people shifts to the «senile» age (76.93 ± 1.32), while among the unimmunized, the age of death is closer to the category of «elderly» (73.74 ± 1.39 years) (p ≤ 0.05). In the structure of mortality among the vaccinated, the main share was made up of patients with a history of 3 to 7 concomitant systemic diseases (66.7%), while among the unvaccinated, the main share (74.5%) were patients either without comorbidities or with a history of 1 to 2 concomitant diseases.Conclusion. The results of the epidemiological features of the COVID-2 epidemic process have shown that vaccination against the SARS-CoV-2 virus is vital for elderly and senile people with comorbid conditions.https://www.epidemvac.ru/jour/article/view/1913covid-19 vaccinationmorbidity of vaccinated peoplelethality of vaccinated people |
| spellingShingle | M. P. Kostinov Chen Zhang I. A. Khrapunova A. S. Pechenik V. A. Brazhnik V. A. Utkin M. N. Laktionova A. V. Linok S. P. Raicic Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions Эпидемиология и вакцинопрофилактика covid-19 vaccination morbidity of vaccinated people lethality of vaccinated people |
| title | Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions |
| title_full | Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions |
| title_fullStr | Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions |
| title_full_unstemmed | Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions |
| title_short | Rationale for Vaccination against COVID-19 among Elderly and Senile People with Comorbid Conditions |
| title_sort | rationale for vaccination against covid 19 among elderly and senile people with comorbid conditions |
| topic | covid-19 vaccination morbidity of vaccinated people lethality of vaccinated people |
| url | https://www.epidemvac.ru/jour/article/view/1913 |
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