Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty
A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome char...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2251589 |
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| _version_ | 1850111181589577728 |
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| author | Xiangqi Li Chaobao Zhang Zhijun Bao |
| author_facet | Xiangqi Li Chaobao Zhang Zhijun Bao |
| author_sort | Xiangqi Li |
| collection | DOAJ |
| description | A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The results revealed that patients with frailty were more prone to poor health conversions and more sequelae, and the blood transcriptome had obvious disturbances in pathways associated with immune regulation, metabolism, and stress response. These adverse health transitions were significantly associated with mast cell activation. Additionally, NCAPG, MCM10, and CDC25C were identified as hub genes in the peripheral blood differential gene cluster, which could be used as diagnostic markers of poor health conversion. Our results indicate that healthcare measures should be prioritized to mitigate adverse health outcomes in this vulnerable patient group, COVID-19 patients with frailty, in post-COVID era. |
| format | Article |
| id | doaj-art-b2df6a7ffdeb48dfab6d76033aad0b94 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-b2df6a7ffdeb48dfab6d76033aad0b942025-08-20T02:37:39ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2251589Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailtyXiangqi Li0Chaobao Zhang1Zhijun Bao2Department of Endocrinology and Metabolism, Gongli Hospital, Naval Medical University, Shanghai, People’s Republic of ChinaShanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaShanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaA prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The results revealed that patients with frailty were more prone to poor health conversions and more sequelae, and the blood transcriptome had obvious disturbances in pathways associated with immune regulation, metabolism, and stress response. These adverse health transitions were significantly associated with mast cell activation. Additionally, NCAPG, MCM10, and CDC25C were identified as hub genes in the peripheral blood differential gene cluster, which could be used as diagnostic markers of poor health conversion. Our results indicate that healthcare measures should be prioritized to mitigate adverse health outcomes in this vulnerable patient group, COVID-19 patients with frailty, in post-COVID era.https://www.tandfonline.com/doi/10.1080/22221751.2023.2251589Long-COVIDmast cellfrailtyetiologytransitions |
| spellingShingle | Xiangqi Li Chaobao Zhang Zhijun Bao Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty Emerging Microbes and Infections Long-COVID mast cell frailty etiology transitions |
| title | Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty |
| title_full | Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty |
| title_fullStr | Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty |
| title_full_unstemmed | Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty |
| title_short | Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty |
| title_sort | mast cell activation may contribute to adverse health transitions in covid 19 patients with frailty |
| topic | Long-COVID mast cell frailty etiology transitions |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2251589 |
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