Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to increased all-cause mortality due to metabolic dysfunctions like obesity, diabetes, and cardiovascular diseases. This study examines the association between Life’s Essential 8 (LE8) scores and both all-...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12889-024-20919-6 |
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| author | Yingying Zhang Pingping Wang Fan Tu Hao Kang Chengfeng Fu |
| author_facet | Yingying Zhang Pingping Wang Fan Tu Hao Kang Chengfeng Fu |
| author_sort | Yingying Zhang |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to increased all-cause mortality due to metabolic dysfunctions like obesity, diabetes, and cardiovascular diseases. This study examines the association between Life’s Essential 8 (LE8) scores and both all-cause and cardiovascular disease (CVD) mortality in MASLD participants. Methods Data from 5,916 MASLD participants in the NHANES (2005–2018) were analyzed. Associations between LE8 scores and all-cause and CVD mortality were assessed using Cox proportional hazards models, with follow-up until December 31, 2019. Dose-response relationships and survival differences were evaluated using Kaplan-Meier survival curves and Restricted Cubic Spline models. Results Over a median follow-up of 7.6 years, moderate and high LE8 scores were associated with 33% (HR: 0.67; 95% CI: 0.56–0.79) and 47% (HR: 0.53; 95% CI: 0.33–0.84) lower risk of all-cause mortality, respectively, compared to low scores. For CVD mortality, the adjusted HRs were 0.56 (95% CI: 0.41–0.78) and 0.35 (95% CI: 0.12-1.0). Higher LE8 scores were significantly associated with reduced cumulative incidence of all-cause and CVD mortality (log-rank P < 0.001). A 10-point increase in health behavior scores, particularly in diet, physical activity, and nicotine exposure, was linked to an 11% reduction in all-cause mortality risk and an 11% reduction in CVD mortality risk. Among health factors, only blood glucose showed a significant association with CVD mortality. Conclusion Higher LE8 scores in MASLD patients are associated with lower mortality risk, suggesting the potential value of promoting cardiovascular health in this population. Further research is needed to confirm these associations. Graphical Abstract |
| format | Article |
| id | doaj-art-b2dbe674ec394cf7ae23bb566c84571a |
| institution | DOAJ |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-b2dbe674ec394cf7ae23bb566c84571a2025-08-20T02:40:17ZengBMCBMC Public Health1471-24582024-12-0124111210.1186/s12889-024-20919-6Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver diseaseYingying Zhang0Pingping Wang1Fan Tu2Hao Kang3Chengfeng Fu4Medical Laboratory Center, Affiliated Wuxi Fifth Hospital of Jiangnan UniversityDepartment of Clinical Laboratory, Taizhou Second People’s Hospital Affiliated to Yangzhou UniversityMedical Laboratory Center, Affiliated Wuxi Fifth Hospital of Jiangnan UniversityResearch Center for Clinical Medical Sciences, Affiliated Wuxi Fifth Hospital of Jiangnan UniversityRespiratory and Critical Care Medicine, The Second People’s Hospital of Banan DistrictAbstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to increased all-cause mortality due to metabolic dysfunctions like obesity, diabetes, and cardiovascular diseases. This study examines the association between Life’s Essential 8 (LE8) scores and both all-cause and cardiovascular disease (CVD) mortality in MASLD participants. Methods Data from 5,916 MASLD participants in the NHANES (2005–2018) were analyzed. Associations between LE8 scores and all-cause and CVD mortality were assessed using Cox proportional hazards models, with follow-up until December 31, 2019. Dose-response relationships and survival differences were evaluated using Kaplan-Meier survival curves and Restricted Cubic Spline models. Results Over a median follow-up of 7.6 years, moderate and high LE8 scores were associated with 33% (HR: 0.67; 95% CI: 0.56–0.79) and 47% (HR: 0.53; 95% CI: 0.33–0.84) lower risk of all-cause mortality, respectively, compared to low scores. For CVD mortality, the adjusted HRs were 0.56 (95% CI: 0.41–0.78) and 0.35 (95% CI: 0.12-1.0). Higher LE8 scores were significantly associated with reduced cumulative incidence of all-cause and CVD mortality (log-rank P < 0.001). A 10-point increase in health behavior scores, particularly in diet, physical activity, and nicotine exposure, was linked to an 11% reduction in all-cause mortality risk and an 11% reduction in CVD mortality risk. Among health factors, only blood glucose showed a significant association with CVD mortality. Conclusion Higher LE8 scores in MASLD patients are associated with lower mortality risk, suggesting the potential value of promoting cardiovascular health in this population. Further research is needed to confirm these associations. Graphical Abstracthttps://doi.org/10.1186/s12889-024-20919-6MASLDLife’s essential 8All-cause mortalityCVD mortalityNational health and nutrition examination survey |
| spellingShingle | Yingying Zhang Pingping Wang Fan Tu Hao Kang Chengfeng Fu Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease BMC Public Health MASLD Life’s essential 8 All-cause mortality CVD mortality National health and nutrition examination survey |
| title | Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease |
| title_full | Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease |
| title_fullStr | Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease |
| title_full_unstemmed | Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease |
| title_short | Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease |
| title_sort | life s essential 8 and mortality in us adults with metabolic dysfunction associated steatotic liver disease |
| topic | MASLD Life’s essential 8 All-cause mortality CVD mortality National health and nutrition examination survey |
| url | https://doi.org/10.1186/s12889-024-20919-6 |
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