Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis
ObjectiveTo investigate the positive rate of hepatitis E virus (HEV) immunoglobulin G (IgG) antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women. MethodsPubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and...
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| Format: | Article |
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Editorial Office of Chinese Journal of Public Health
2025-02-01
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| Series: | Zhongguo gonggong weisheng |
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| Online Access: | https://www.zgggws.com/article/doi/10.11847/zgggws1144785 |
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| author | Qixin XIE Chunmei YE Zhaojun LU Wenwen GU Jing WANG Jian DU Yingying YANG Yan LIU |
| author_facet | Qixin XIE Chunmei YE Zhaojun LU Wenwen GU Jing WANG Jian DU Yingying YANG Yan LIU |
| author_sort | Qixin XIE |
| collection | DOAJ |
| description | ObjectiveTo investigate the positive rate of hepatitis E virus (HEV) immunoglobulin G (IgG) antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women. MethodsPubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched, supplemented by a retrospective literature search, to collect relevant literature published domestically and internationally from January 1, 1989, to December 31, 2023, on the seroprevalence of HEV in pregnant women in China. R 3.5.2 software was used for meta-analysis of the included literature. ResultsA total of 15 articles (8 in Chinese and 7 in English) were included, with a cumulative study population of 36 188. The meta-analysis showed that the positive rate of HEV IgG antibodies among pregnant women in China was 13% (95% confidence interval [95%CI]: 11%–16%). Subgroup analysis showed that the positive rates of HEV IgG antibodies in pregnant women younger than 30 years old and 30 years old and older were 18% (95%CI: 12%–24%) and 15% (95%CI: 10%–19%), respectively; the positive rates of HEV IgG antibodies in pregnant women living in urban and rural areas were 29% (95%CI: 3%–55%) and 25% (95%CI: 5%–45%), respectively; and the positive rates of HEV IgG antibodies in pregnant women in the first, second, and third trimesters were 16% (95%CI: 3%–28%), 13% (95%CI: 7%–18%), and 15% (95%CI: 10%–21%), respectively. There were no statistically significant differences in the positive rates of HEV IgG antibodies among pregnant women of different ages, residences, and gestational ages (all P>0.05). Sensitivity analysis and publication bias tests showed that there was no publication bias in the literature included in this meta-analysis, and the results were relatively stable. ConclusionsThe positive rate of HEV IgG antibodies among pregnant women in China is relatively high. Attention should be paid to this high-risk group, and prevention and control measures for HEV infection should be strengthened. |
| format | Article |
| id | doaj-art-b2da2f31133c4561a0eaa8608a083abb |
| institution | OA Journals |
| issn | 1001-0580 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Chinese Journal of Public Health |
| record_format | Article |
| series | Zhongguo gonggong weisheng |
| spelling | doaj-art-b2da2f31133c4561a0eaa8608a083abb2025-08-20T01:48:23ZzhoEditorial Office of Chinese Journal of Public HealthZhongguo gonggong weisheng1001-05802025-02-0141223423810.11847/zgggws11447851144785Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysisQixin XIE0Chunmei YE1Zhaojun LU2Wenwen GU3Jing WANG4Jian DU5Yingying YANG6Yan LIU7Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Linping District Center for Disease Control and Prevention (Hangzhou Linping District Health Supervision Institution), Hangzhou 311222, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaHangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310000, ChinaObjectiveTo investigate the positive rate of hepatitis E virus (HEV) immunoglobulin G (IgG) antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women. MethodsPubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched, supplemented by a retrospective literature search, to collect relevant literature published domestically and internationally from January 1, 1989, to December 31, 2023, on the seroprevalence of HEV in pregnant women in China. R 3.5.2 software was used for meta-analysis of the included literature. ResultsA total of 15 articles (8 in Chinese and 7 in English) were included, with a cumulative study population of 36 188. The meta-analysis showed that the positive rate of HEV IgG antibodies among pregnant women in China was 13% (95% confidence interval [95%CI]: 11%–16%). Subgroup analysis showed that the positive rates of HEV IgG antibodies in pregnant women younger than 30 years old and 30 years old and older were 18% (95%CI: 12%–24%) and 15% (95%CI: 10%–19%), respectively; the positive rates of HEV IgG antibodies in pregnant women living in urban and rural areas were 29% (95%CI: 3%–55%) and 25% (95%CI: 5%–45%), respectively; and the positive rates of HEV IgG antibodies in pregnant women in the first, second, and third trimesters were 16% (95%CI: 3%–28%), 13% (95%CI: 7%–18%), and 15% (95%CI: 10%–21%), respectively. There were no statistically significant differences in the positive rates of HEV IgG antibodies among pregnant women of different ages, residences, and gestational ages (all P>0.05). Sensitivity analysis and publication bias tests showed that there was no publication bias in the literature included in this meta-analysis, and the results were relatively stable. ConclusionsThe positive rate of HEV IgG antibodies among pregnant women in China is relatively high. Attention should be paid to this high-risk group, and prevention and control measures for HEV infection should be strengthened.https://www.zgggws.com/article/doi/10.11847/zgggws1144785hepatitis e virusimmunoglobulin g antibodypositive ratepregnant womenchinameta-analysis |
| spellingShingle | Qixin XIE Chunmei YE Zhaojun LU Wenwen GU Jing WANG Jian DU Yingying YANG Yan LIU Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis Zhongguo gonggong weisheng hepatitis e virus immunoglobulin g antibody positive rate pregnant women china meta-analysis |
| title | Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis |
| title_full | Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis |
| title_fullStr | Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis |
| title_full_unstemmed | Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis |
| title_short | Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis |
| title_sort | positive rates of hepatitis e virus igg antibodies in pregnant women in china a meta analysis |
| topic | hepatitis e virus immunoglobulin g antibody positive rate pregnant women china meta-analysis |
| url | https://www.zgggws.com/article/doi/10.11847/zgggws1144785 |
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