Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep
<b>Aim: </b>The aim of the study was to determine the effect of intravenous administration of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological, biochemical and coagulation parameters in sheep.<p> <b>Materials and Methods: </b>Clinically healthy sheep...
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| Language: | English |
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Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1370 |
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| author | Fulya Altınok Yipel Hüseyin Güngör |
| author_facet | Fulya Altınok Yipel Hüseyin Güngör |
| author_sort | Fulya Altınok Yipel |
| collection | DOAJ |
| description | <b>Aim: </b>The aim of the study was to determine the effect of intravenous administration
of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological,
biochemical and coagulation parameters in sheep.<p>
<b>Materials and Methods: </b>Clinically healthy sheep were randomly divided
into groups as Group 1 (n:6), Group 2 (n:6) and Group 3 (n:6). Meloxicam
was administered intravenously as a single dose of 0,5 mg/kg in Group 1,
1 mg/kg in Group 2 and 2 mg/kg in Group 3. To determine the effect of
increasing single doses of meloxicam on hematological, biochemical and
coagulation factors, blood samples were collected at 0, 24, and 72 hours. In
addition, hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV,
PDW, PCT, PLT) and biochemical parameters (AST, ALT, ALP, GGT, TP, UREA,
CREA, CHOL, TRIG, ALB) ) and the levels of coagulation parameters (PT,
APTT, INR, FIB) were determined.<p>
<b>Results: </b>In groups; Differences in biochemical parameters other than
UREA and parameters of RBC, HCT, MCV, MCHC, MPV were statistically significant
(p<0,05). It was observed that there was no statistically significant
difference in terms of their relationship with hemostatic blood parameter
levels.<p>
<b>Conclusion:</b> In conclusion, it is thought that further studies techniques
such as molecular diagnostic methods are needed in terms of hemostatic,
hematological and biochemical effects of increasing single doses of meloxicam
in sheep. |
| format | Article |
| id | doaj-art-b2d43565efc841bc8fb728335d3c9643 |
| institution | DOAJ |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-b2d43565efc841bc8fb728335d3c96432025-08-20T02:58:10ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-12-013742432511370Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheepFulya Altınok Yipel0Hüseyin Güngör1Hatay Mustafa Kemal Üniversitesi Samandağ Meslek Yüksekokulu Laborant ve Veteriner Sağlık Programı, Hatay, TürkiyeSivas Üniversitesi Veteriner Fakültesi Farmakoloji ve Toksikoloji Anabilim Dalı, Sivas, Türkiye<b>Aim: </b>The aim of the study was to determine the effect of intravenous administration of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological, biochemical and coagulation parameters in sheep.<p> <b>Materials and Methods: </b>Clinically healthy sheep were randomly divided into groups as Group 1 (n:6), Group 2 (n:6) and Group 3 (n:6). Meloxicam was administered intravenously as a single dose of 0,5 mg/kg in Group 1, 1 mg/kg in Group 2 and 2 mg/kg in Group 3. To determine the effect of increasing single doses of meloxicam on hematological, biochemical and coagulation factors, blood samples were collected at 0, 24, and 72 hours. In addition, hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV, PDW, PCT, PLT) and biochemical parameters (AST, ALT, ALP, GGT, TP, UREA, CREA, CHOL, TRIG, ALB) ) and the levels of coagulation parameters (PT, APTT, INR, FIB) were determined.<p> <b>Results: </b>In groups; Differences in biochemical parameters other than UREA and parameters of RBC, HCT, MCV, MCHC, MPV were statistically significant (p<0,05). It was observed that there was no statistically significant difference in terms of their relationship with hemostatic blood parameter levels.<p> <b>Conclusion:</b> In conclusion, it is thought that further studies techniques such as molecular diagnostic methods are needed in terms of hemostatic, hematological and biochemical effects of increasing single doses of meloxicam in sheep.http://eurasianjvetsci.org/pdf.php3?id=1370biochemical parametershemogramcoagulation parameterssheepmeloxicam |
| spellingShingle | Fulya Altınok Yipel Hüseyin Güngör Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep Eurasian Journal of Veterinary Sciences biochemical parameters hemogram coagulation parameters sheep meloxicam |
| title | Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep |
| title_full | Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep |
| title_fullStr | Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep |
| title_full_unstemmed | Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep |
| title_short | Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep |
| title_sort | evaluation of the effects of increasing doses of meloxicam on hematological biochemical and hemostatic blood parameters in sheep |
| topic | biochemical parameters hemogram coagulation parameters sheep meloxicam |
| url | http://eurasianjvetsci.org/pdf.php3?id=1370 |
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