Magnesium and Vascular Changes in Hypertension
Many factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. There is a significant inverse correlation between serum magnesium and incidence of cardiovascular diseases. Magnesium is a mineral w...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/754250 |
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| _version_ | 1832551484667985920 |
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| author | Ana Rosa Cunha Bianca Umbelino Margarida L. Correia Mario Fritsch Neves |
| author_facet | Ana Rosa Cunha Bianca Umbelino Margarida L. Correia Mario Fritsch Neves |
| author_sort | Ana Rosa Cunha |
| collection | DOAJ |
| description | Many factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. There is a significant inverse correlation between serum magnesium and incidence of cardiovascular diseases. Magnesium is a mineral with important functions in the body such as antiarrhythmic effect, actions in vascular tone, contractility, glucose metabolism, and insulin homeostasis. In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. The conflicting results of studies evaluating the effects of magnesium supplements on blood pressure and other cardiovascular outcomes indicate that the action of magnesium in the vascular system is present but not yet established. Therefore, this mineral supplementation is not indicated as part of antihypertensive treatment, and further studies are needed to better clarify the role of magnesium in the prevention and treatment of cardiovascular diseases. |
| format | Article |
| id | doaj-art-b2d30aaba2894ad19e983223aee85d80 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b2d30aaba2894ad19e983223aee85d802025-02-03T06:01:26ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/754250754250Magnesium and Vascular Changes in HypertensionAna Rosa Cunha0Bianca Umbelino1Margarida L. Correia2Mario Fritsch Neves3Department of Clinical Medicine, University Hospital Pedro Ernesto, State University of Rio de Janeiro, Avenida 28 de Setembro, 77 Sala 329, 20551-030, Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, University Hospital Pedro Ernesto, State University of Rio de Janeiro, Avenida 28 de Setembro, 77 Sala 329, 20551-030, Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, University Hospital Pedro Ernesto, State University of Rio de Janeiro, Avenida 28 de Setembro, 77 Sala 329, 20551-030, Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, University Hospital Pedro Ernesto, State University of Rio de Janeiro, Avenida 28 de Setembro, 77 Sala 329, 20551-030, Rio de Janeiro, RJ, BrazilMany factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. There is a significant inverse correlation between serum magnesium and incidence of cardiovascular diseases. Magnesium is a mineral with important functions in the body such as antiarrhythmic effect, actions in vascular tone, contractility, glucose metabolism, and insulin homeostasis. In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. The conflicting results of studies evaluating the effects of magnesium supplements on blood pressure and other cardiovascular outcomes indicate that the action of magnesium in the vascular system is present but not yet established. Therefore, this mineral supplementation is not indicated as part of antihypertensive treatment, and further studies are needed to better clarify the role of magnesium in the prevention and treatment of cardiovascular diseases.http://dx.doi.org/10.1155/2012/754250 |
| spellingShingle | Ana Rosa Cunha Bianca Umbelino Margarida L. Correia Mario Fritsch Neves Magnesium and Vascular Changes in Hypertension International Journal of Hypertension |
| title | Magnesium and Vascular Changes in Hypertension |
| title_full | Magnesium and Vascular Changes in Hypertension |
| title_fullStr | Magnesium and Vascular Changes in Hypertension |
| title_full_unstemmed | Magnesium and Vascular Changes in Hypertension |
| title_short | Magnesium and Vascular Changes in Hypertension |
| title_sort | magnesium and vascular changes in hypertension |
| url | http://dx.doi.org/10.1155/2012/754250 |
| work_keys_str_mv | AT anarosacunha magnesiumandvascularchangesinhypertension AT biancaumbelino magnesiumandvascularchangesinhypertension AT margaridalcorreia magnesiumandvascularchangesinhypertension AT mariofritschneves magnesiumandvascularchangesinhypertension |