Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial
Introduction: Bacillus Calmette-Guérin (BCG) vaccination induces innate and specific responses that protect against some severe forms of tuberculosis and have nonspecific effects against other infections. Objective: To evaluate whether revaccination with BCG Moscow is associated with serum increase...
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| Format: | Article |
| Language: | English |
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Faculdade de Medicina do ABC
2025-04-01
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| Series: | ABCS Health Sciences |
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| Online Access: | https://www.portalnepas.org.br/abcshs/article/view/2433 |
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| author | Amanda da Rocha Oliveira Cardoso Marcus Barreto Conte Laura Raniere Borges dos Anjos Ana Paula Junqueira-Kipnis Marcelo Fouad Rabahi |
| author_facet | Amanda da Rocha Oliveira Cardoso Marcus Barreto Conte Laura Raniere Borges dos Anjos Ana Paula Junqueira-Kipnis Marcelo Fouad Rabahi |
| author_sort | Amanda da Rocha Oliveira Cardoso |
| collection | DOAJ |
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Introduction: Bacillus Calmette-Guérin (BCG) vaccination induces innate and specific responses that protect against some severe forms of tuberculosis and have nonspecific effects against other infections. Objective: To evaluate whether revaccination with BCG Moscow is associated with serum increase in total and differential leukocytes. Methods: We conducted an analytical study on the white blood cell count of 156 participants (BCG revaccination group: 80; Control group: 76) of a randomized clinical trial investigating BCG revaccination for the prevention or reduction of complications associated with COVID-19. Blood samples were collected before randomization and after 15 days of intervention. Values were expressed as mean (μ) and standard deviation, using paired t-tests and Student's t-test. Results: BCG revaccination did not alter leukocyte levels between revaccinated (μ, 6019.74±1865.33) and non-revaccinated groups (μ, 6278.75±1823.87), p=0.94. Stratification by sex, obesity, and age did not significantly affect white blood cell levels. Conclusion: Revaccination with BCG Moscow did not stimulate leukocyte production.
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| format | Article |
| id | doaj-art-b2d28de473f44ec1a5d7abfa03126202 |
| institution | OA Journals |
| issn | 2318-4965 2357-8114 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Faculdade de Medicina do ABC |
| record_format | Article |
| series | ABCS Health Sciences |
| spelling | doaj-art-b2d28de473f44ec1a5d7abfa031262022025-08-20T02:18:35ZengFaculdade de Medicina do ABCABCS Health Sciences2318-49652357-81142025-04-0110.7322/abcshs.2023148.2433Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trialAmanda da Rocha Oliveira Cardoso0Marcus Barreto Conte 1Laura Raniere Borges dos Anjos 2Ana Paula Junqueira-Kipnis3Marcelo Fouad Rabahi4Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Goiás (UFG) – Goiânia (GO), BrazilFaculdade de Medicina de Petrópolis, Centro Universitário Arthur Sá Earp Neto (FMP/UNIFASE) – Petrópolis (RJ), BrazilPrograma de Pós-Graduação em Biotecnologia e Biodiversidade, UFG – Goiânia (GO), BrazilInstituto de Patologia Tropical e Saúde Pública, UFG – Goiânia (GO), BrazilFaculdade de Medicina, UFG – Goiânia (GO), Brazil Introduction: Bacillus Calmette-Guérin (BCG) vaccination induces innate and specific responses that protect against some severe forms of tuberculosis and have nonspecific effects against other infections. Objective: To evaluate whether revaccination with BCG Moscow is associated with serum increase in total and differential leukocytes. Methods: We conducted an analytical study on the white blood cell count of 156 participants (BCG revaccination group: 80; Control group: 76) of a randomized clinical trial investigating BCG revaccination for the prevention or reduction of complications associated with COVID-19. Blood samples were collected before randomization and after 15 days of intervention. Values were expressed as mean (μ) and standard deviation, using paired t-tests and Student's t-test. Results: BCG revaccination did not alter leukocyte levels between revaccinated (μ, 6019.74±1865.33) and non-revaccinated groups (μ, 6278.75±1823.87), p=0.94. Stratification by sex, obesity, and age did not significantly affect white blood cell levels. Conclusion: Revaccination with BCG Moscow did not stimulate leukocyte production. https://www.portalnepas.org.br/abcshs/article/view/2433BCG vaccineimmunization, secondaryLeukocytes |
| spellingShingle | Amanda da Rocha Oliveira Cardoso Marcus Barreto Conte Laura Raniere Borges dos Anjos Ana Paula Junqueira-Kipnis Marcelo Fouad Rabahi Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial ABCS Health Sciences BCG vaccine immunization, secondary Leukocytes |
| title | Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial |
| title_full | Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial |
| title_fullStr | Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial |
| title_full_unstemmed | Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial |
| title_short | Effects of Bacillus Calmette-Guérin (BCG Moscow) vaccination on white blood cell count: results of a randomized clinical trial |
| title_sort | effects of bacillus calmette guerin bcg moscow vaccination on white blood cell count results of a randomized clinical trial |
| topic | BCG vaccine immunization, secondary Leukocytes |
| url | https://www.portalnepas.org.br/abcshs/article/view/2433 |
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