Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials
This meta-analysis aims to compare chest compression-only cardiopulmonary resuscitation (CO-CPR) with standard CPR (sCPR), which includes mouth-to-mouth ventilation, as potential strategies for managing out-of-hospital cardiac arrest (OHCA). We systematically searched various databases and registri...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-05-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3362 |
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| author | Arshbeer Singh Sandhu Muhammad Arslan Arif Maan Ogechukwu Obi Oliver Hervir Mark Abdelnour Nayan Gandhi Mansoureh Fatahi Abuelgasim Mohamed Ratan Pal Yadav Jassim Zaheen Shah Muhammad Ehsan Wajeeh Ur Rehman |
| author_facet | Arshbeer Singh Sandhu Muhammad Arslan Arif Maan Ogechukwu Obi Oliver Hervir Mark Abdelnour Nayan Gandhi Mansoureh Fatahi Abuelgasim Mohamed Ratan Pal Yadav Jassim Zaheen Shah Muhammad Ehsan Wajeeh Ur Rehman |
| author_sort | Arshbeer Singh Sandhu |
| collection | DOAJ |
| description |
This meta-analysis aims to compare chest compression-only cardiopulmonary resuscitation (CO-CPR) with standard CPR (sCPR), which includes mouth-to-mouth ventilation, as potential strategies for managing out-of-hospital cardiac arrest (OHCA). We systematically searched various databases and registries such as MEDLINE, Embase, The Cochrane Library, and Clinicaltrials.gov to retrieve relevant studies. We used the revised Cochrane “Risk of Bias” tool for randomized trials (RoB 2.0) to assess the risk of bias in included studies. Revman 5.4 was used to pool dichotomous outcomes under a random effects model. A total of 4 randomized controlled trials were included in our meta-analysis. Our results indicate that CO-CPR was associated with a significantly increased survival to hospital discharge compared to sCPR [relative risk (RR) 1.22, 95% confidence interval (CI): 1.01 to 1.46] with minimal heterogeneity (I2=0%). No significant difference was observed between the two groups regarding 1-day survival (RR 1.07, 95% CI: 0.94 to 1.23), survival to hospital admission with a good neurological outcome (cerebral performance category 1 or 2) (RR 1.10, 95% CI: 0.80 to 1.51), return of spontaneous circulation (RR 1.05, 95% CI: 0.95 to 1.17), and survival to hospital admission (RR 1.08, 95% CI: 0.93 to 1.25). This meta-analysis found that chest CO-CPR significantly improves survival to hospital discharge compared to sCPR for managing OHCA, while yielding comparable results for other resuscitation outcomes.
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| format | Article |
| id | doaj-art-b2cd86a7f1bc4ef780535255adab6639 |
| institution | Kabale University |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-b2cd86a7f1bc4ef780535255adab66392025-08-20T03:53:51ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-05-0110.4081/monaldi.2025.3362Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trialsArshbeer Singh Sandhu0Muhammad Arslan Arif Maan1Ogechukwu Obi2https://orcid.org/0000-0003-4184-9644Oliver Hervir3Mark Abdelnour4https://orcid.org/0009-0009-3584-9825Nayan Gandhi5https://orcid.org/0009-0004-8367-6053Mansoureh Fatahi6https://orcid.org/0009-0004-0026-912XAbuelgasim Mohamed7https://orcid.org/0000-0002-2282-9202Ratan Pal Yadav8Jassim Zaheen Shah9https://orcid.org/0009-0004-8210-1282Muhammad Ehsan10Wajeeh Ur Rehman11https://orcid.org/0000-0002-4520-2373Department of Neurosciences, University Hospital Coventry and Warwickshire NHS Trust, Coventry, EnglandDepartment of Medicine, UnityPoint Health, St. Lukes Hospital, Cedar Rapids, IowaNew York Institute of Technology, College of Osteopathic Medicine, New YorkSchool of Medicine, Faculty of Medicine and Health, University of Sydney, CamperdownDepartment of Medicine, University of California Irvine Medical Center, Orange, CaliforniaGCS Medical College Hospital and Research Center, Ahmedabad, GujaratEmergency Department, Shahid Beheshti University of Medical Sciences, TehranFaculty of Medicine, Al Neelain University, KhartoumDepartment of Medicine, NRI Medical College, GunturDepartment of Cardiology, Heart Hospital, DohaDepartment of Medicine, King Edward Medical University, LahoreDepartment of Medicine, United Health Services, Johnson City, New York This meta-analysis aims to compare chest compression-only cardiopulmonary resuscitation (CO-CPR) with standard CPR (sCPR), which includes mouth-to-mouth ventilation, as potential strategies for managing out-of-hospital cardiac arrest (OHCA). We systematically searched various databases and registries such as MEDLINE, Embase, The Cochrane Library, and Clinicaltrials.gov to retrieve relevant studies. We used the revised Cochrane “Risk of Bias” tool for randomized trials (RoB 2.0) to assess the risk of bias in included studies. Revman 5.4 was used to pool dichotomous outcomes under a random effects model. A total of 4 randomized controlled trials were included in our meta-analysis. Our results indicate that CO-CPR was associated with a significantly increased survival to hospital discharge compared to sCPR [relative risk (RR) 1.22, 95% confidence interval (CI): 1.01 to 1.46] with minimal heterogeneity (I2=0%). No significant difference was observed between the two groups regarding 1-day survival (RR 1.07, 95% CI: 0.94 to 1.23), survival to hospital admission with a good neurological outcome (cerebral performance category 1 or 2) (RR 1.10, 95% CI: 0.80 to 1.51), return of spontaneous circulation (RR 1.05, 95% CI: 0.95 to 1.17), and survival to hospital admission (RR 1.08, 95% CI: 0.93 to 1.25). This meta-analysis found that chest CO-CPR significantly improves survival to hospital discharge compared to sCPR for managing OHCA, while yielding comparable results for other resuscitation outcomes. https://www.monaldi-archives.org/macd/article/view/3362CPROHCAcardiac arrestcardiopulmonary resuscitation |
| spellingShingle | Arshbeer Singh Sandhu Muhammad Arslan Arif Maan Ogechukwu Obi Oliver Hervir Mark Abdelnour Nayan Gandhi Mansoureh Fatahi Abuelgasim Mohamed Ratan Pal Yadav Jassim Zaheen Shah Muhammad Ehsan Wajeeh Ur Rehman Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials Monaldi Archives for Chest Disease CPR OHCA cardiac arrest cardiopulmonary resuscitation |
| title | Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | compression only or standard cardiopulmonary resuscitation for out of hospital cardiac arrest a systematic review and meta analysis of randomized controlled trials |
| topic | CPR OHCA cardiac arrest cardiopulmonary resuscitation |
| url | https://www.monaldi-archives.org/macd/article/view/3362 |
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