Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions
Solid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivation. HIF-1α controls gene expression associated with various si...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2024/5523283 |
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| _version_ | 1850159652580360192 |
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| author | Jesús Valencia-Cervantes Martha Patricia Sierra-Vargas |
| author_facet | Jesús Valencia-Cervantes Martha Patricia Sierra-Vargas |
| author_sort | Jesús Valencia-Cervantes |
| collection | DOAJ |
| description | Solid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivation. HIF-1α controls gene expression associated with various signaling pathways that promote cancer cell proliferation and survival. MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells. |
| format | Article |
| id | doaj-art-b2c4ea37317d415dafbbf61f33abdf74 |
| institution | OA Journals |
| issn | 2210-7185 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-b2c4ea37317d415dafbbf61f33abdf742025-08-20T02:23:27ZengWileyAnalytical Cellular Pathology2210-71852024-01-01202410.1155/2024/5523283Regulation of Cancer-Associated miRNAs Expression under Hypoxic ConditionsJesús Valencia-Cervantes0Martha Patricia Sierra-Vargas1Departamento de Investigación en Toxicología y Medicina AmbientalDepartamento de Investigación en Toxicología y Medicina AmbientalSolid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivation. HIF-1α controls gene expression associated with various signaling pathways that promote cancer cell proliferation and survival. MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells.http://dx.doi.org/10.1155/2024/5523283 |
| spellingShingle | Jesús Valencia-Cervantes Martha Patricia Sierra-Vargas Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions Analytical Cellular Pathology |
| title | Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions |
| title_full | Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions |
| title_fullStr | Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions |
| title_full_unstemmed | Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions |
| title_short | Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions |
| title_sort | regulation of cancer associated mirnas expression under hypoxic conditions |
| url | http://dx.doi.org/10.1155/2024/5523283 |
| work_keys_str_mv | AT jesusvalenciacervantes regulationofcancerassociatedmirnasexpressionunderhypoxicconditions AT marthapatriciasierravargas regulationofcancerassociatedmirnasexpressionunderhypoxicconditions |