Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy
Brain anatomical alterations in gray matter(GM), white matter(WM), and glymphatic system(GS) in patients with hepatitis B cirrhosis(HBC) with minimal hepatic encephalopathy(MHE) remain to be clarified. A total of 33 healthy controls and 37 patients with treatment-native primary HBC (further subdivid...
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Elsevier
2025-08-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S036192302500228X |
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| author | Chao Ju Longtao Yang Zhongshang Dai Yisong Wang Chang Li Wei Zhao Yongfang Jiang Haiyang Li Jun Liu |
| author_facet | Chao Ju Longtao Yang Zhongshang Dai Yisong Wang Chang Li Wei Zhao Yongfang Jiang Haiyang Li Jun Liu |
| author_sort | Chao Ju |
| collection | DOAJ |
| description | Brain anatomical alterations in gray matter(GM), white matter(WM), and glymphatic system(GS) in patients with hepatitis B cirrhosis(HBC) with minimal hepatic encephalopathy(MHE) remain to be clarified. A total of 33 healthy controls and 37 patients with treatment-native primary HBC (further subdivided into HBC in MHE group[MHE] and HBC in non-MHE group[NMHE]) participated in neuroimaging study with three-dimensional T1 and a half q-space Cartesian grid diffusion model. Group differences in regional GM volume(GMV) were assessed using voxel-based morphometry(VBM) analysis. Differences in WM diffusion metrics were compared using tract-based spatial statistics(TBSS) analysis. Diffusion tensor image analysis along the perivascular space(DTI-ALPS) was employed to evaluate GS function. Compared to healthy control group (HC), GMV was reduced in MHE group, mainly in the vermis, bilateral pallidum, and right putamen, but was increased in right lateral geniculate thalamus(Thal_LGN_R) and left pulvinar medial thalamus(Thal_PuM_L). MHE patients displayed greater isotropic volume fraction(ISOVF) in the right sagittal stratum, right superior longitudinal fasciculus, left fornix(cres)/stria terminalis, left corticospinal tract, left cerebral peduncle, and left cingulum (hippocampus) than HC. DTI-ALPS was significantly downregulated in MHE patients. It revealed cortical changes, low-grade WM edema, and GS disorders at the early stage of chronic HBC, which will aid in MHE identification. |
| format | Article |
| id | doaj-art-b2c4b945c4af4c7db6939d6375ec4fd3 |
| institution | OA Journals |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-b2c4b945c4af4c7db6939d6375ec4fd32025-08-20T02:30:54ZengElsevierBrain Research Bulletin1873-27472025-08-0122811141610.1016/j.brainresbull.2025.111416Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathyChao Ju0Longtao Yang1Zhongshang Dai2Yisong Wang3Chang Li4Wei Zhao5Yongfang Jiang6Haiyang Li7Jun Liu8Department of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; FuRong Laboratory, Changsha, Hunan 410078, China; Clinical Research Center For Viral Hepatitis In Hunan Province, Hunan, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; FuRong Laboratory, Changsha, Hunan 410078, China; Clinical Research Center For Viral Hepatitis In Hunan Province, Hunan, China; Corresponding author at: Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, China; Corresponding author.Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China; Department of Radiology Quality Control Center in Hunan Province, Changsha, China; Clinical Research Center for Medical Imaging in Hunan Province, Changsha, China; Corresponding author at: Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.Brain anatomical alterations in gray matter(GM), white matter(WM), and glymphatic system(GS) in patients with hepatitis B cirrhosis(HBC) with minimal hepatic encephalopathy(MHE) remain to be clarified. A total of 33 healthy controls and 37 patients with treatment-native primary HBC (further subdivided into HBC in MHE group[MHE] and HBC in non-MHE group[NMHE]) participated in neuroimaging study with three-dimensional T1 and a half q-space Cartesian grid diffusion model. Group differences in regional GM volume(GMV) were assessed using voxel-based morphometry(VBM) analysis. Differences in WM diffusion metrics were compared using tract-based spatial statistics(TBSS) analysis. Diffusion tensor image analysis along the perivascular space(DTI-ALPS) was employed to evaluate GS function. Compared to healthy control group (HC), GMV was reduced in MHE group, mainly in the vermis, bilateral pallidum, and right putamen, but was increased in right lateral geniculate thalamus(Thal_LGN_R) and left pulvinar medial thalamus(Thal_PuM_L). MHE patients displayed greater isotropic volume fraction(ISOVF) in the right sagittal stratum, right superior longitudinal fasciculus, left fornix(cres)/stria terminalis, left corticospinal tract, left cerebral peduncle, and left cingulum (hippocampus) than HC. DTI-ALPS was significantly downregulated in MHE patients. It revealed cortical changes, low-grade WM edema, and GS disorders at the early stage of chronic HBC, which will aid in MHE identification.http://www.sciencedirect.com/science/article/pii/S036192302500228XHepatitis B cirrhosisMinimal hepatic encephalopathyVoxel-based morphometryTract-based spatial statisticsDiffusion tensor image analysis along the perivascular space |
| spellingShingle | Chao Ju Longtao Yang Zhongshang Dai Yisong Wang Chang Li Wei Zhao Yongfang Jiang Haiyang Li Jun Liu Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy Brain Research Bulletin Hepatitis B cirrhosis Minimal hepatic encephalopathy Voxel-based morphometry Tract-based spatial statistics Diffusion tensor image analysis along the perivascular space |
| title | Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy |
| title_full | Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy |
| title_fullStr | Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy |
| title_full_unstemmed | Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy |
| title_short | Associations among neuropsychological performance, brain structural alterations, and glymphatic function in patients with minimal hepatic encephalopathy |
| title_sort | associations among neuropsychological performance brain structural alterations and glymphatic function in patients with minimal hepatic encephalopathy |
| topic | Hepatitis B cirrhosis Minimal hepatic encephalopathy Voxel-based morphometry Tract-based spatial statistics Diffusion tensor image analysis along the perivascular space |
| url | http://www.sciencedirect.com/science/article/pii/S036192302500228X |
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