Wound healing activity of extract of Gratiola officinalis in vivo
Background and aim — Gratiola officinalis extract has antimicrobial properties, but its wound healing activity has not been described. Material and Methods — The aqueous solution of dry Gratiola officinalis extract was used for treatment of skin wounds with different routes of administration. In th...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2021-12-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/420 |
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| author | Artyom M. Mylnikov Dmitry A. Mudrak Nikita A. Navolokin Yulia A. Khramova Alla B. Bucharskaya Natalya V. Polukonova Galina N. Maslyakova |
| author_facet | Artyom M. Mylnikov Dmitry A. Mudrak Nikita A. Navolokin Yulia A. Khramova Alla B. Bucharskaya Natalya V. Polukonova Galina N. Maslyakova |
| author_sort | Artyom M. Mylnikov |
| collection | DOAJ |
| description | Background and aim — Gratiola officinalis extract has antimicrobial properties, but its wound healing activity has not been described.
Material and Methods — The aqueous solution of dry Gratiola officinalis extract was used for treatment of skin wounds with different routes of administration. In the experiment 40 white laboratory male rats with weight of 150±50 grams were subjected to the incised model of flat skin wounds in the interscapular region under the general anesthesia. A morphological study was carried out to assess the effectiveness of the therapy administered.
Results — The most effective method of treatment was found to be local application of the extract, which reduced wound healing time by 8 days. Intramuscular and oral administrations reduce healing time by 6 days. Morphological signs of regeneration, which developed under the influence of Gratiola officinalis extract, allowed to estimate the wound healing activity. Clear differentiation and thickness of layers of the newly formed epidermis, a large number of thin-walled vessels and actively proliferating fibroblasts indicate an active regeneration process.
Conclusion — This extract may be interesting to specialists in regenerative medicine as a remedy for treatment of wound processes. |
| format | Article |
| id | doaj-art-b2c4a86f34ae4c4590f49bb5825b7b03 |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-b2c4a86f34ae4c4590f49bb5825b7b032025-08-20T03:07:33ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152021-12-01104e041310.15275/rusomj.2021.0413Wound healing activity of extract of Gratiola officinalis in vivoArtyom M. MylnikovDmitry A. MudrakNikita A. NavolokinYulia A. KhramovaAlla B. BucharskayaNatalya V. PolukonovaGalina N. MaslyakovaBackground and aim — Gratiola officinalis extract has antimicrobial properties, but its wound healing activity has not been described. Material and Methods — The aqueous solution of dry Gratiola officinalis extract was used for treatment of skin wounds with different routes of administration. In the experiment 40 white laboratory male rats with weight of 150±50 grams were subjected to the incised model of flat skin wounds in the interscapular region under the general anesthesia. A morphological study was carried out to assess the effectiveness of the therapy administered. Results — The most effective method of treatment was found to be local application of the extract, which reduced wound healing time by 8 days. Intramuscular and oral administrations reduce healing time by 6 days. Morphological signs of regeneration, which developed under the influence of Gratiola officinalis extract, allowed to estimate the wound healing activity. Clear differentiation and thickness of layers of the newly formed epidermis, a large number of thin-walled vessels and actively proliferating fibroblasts indicate an active regeneration process. Conclusion — This extract may be interesting to specialists in regenerative medicine as a remedy for treatment of wound processes.https://romj.org/node/420gratiola officinalisquercetinflavonoid-containing extractwound-healing activityexperimental model |
| spellingShingle | Artyom M. Mylnikov Dmitry A. Mudrak Nikita A. Navolokin Yulia A. Khramova Alla B. Bucharskaya Natalya V. Polukonova Galina N. Maslyakova Wound healing activity of extract of Gratiola officinalis in vivo Russian Open Medical Journal gratiola officinalis quercetin flavonoid-containing extract wound-healing activity experimental model |
| title | Wound healing activity of extract of Gratiola officinalis in vivo |
| title_full | Wound healing activity of extract of Gratiola officinalis in vivo |
| title_fullStr | Wound healing activity of extract of Gratiola officinalis in vivo |
| title_full_unstemmed | Wound healing activity of extract of Gratiola officinalis in vivo |
| title_short | Wound healing activity of extract of Gratiola officinalis in vivo |
| title_sort | wound healing activity of extract of gratiola officinalis in vivo |
| topic | gratiola officinalis quercetin flavonoid-containing extract wound-healing activity experimental model |
| url | https://romj.org/node/420 |
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