Pharmacogenomic tests in Oncology - finding the right dose
A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA). Drug -gene pairs were selected for PGx testing based on the presence of clinically validated PGx associations and the availability of interna...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2021-10-01
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| Series: | Brazilian Journal of Oncology |
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| Online Access: | http://www.brazilianjournalofoncology.com.br/details/153/en-US/pharmacogenomic-tests-in-oncology---finding-the-right-dose |
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| _version_ | 1849396450097627136 |
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| author | Jeziel Basso Gilberto Schwartsmann |
| author_facet | Jeziel Basso Gilberto Schwartsmann |
| author_sort | Jeziel Basso |
| collection | DOAJ |
| description | A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA). Drug -gene pairs were selected for PGx testing based on the presence of clinically validated PGx associations and the availability of international guidelines with PGx-informed dosing recommendations. Fluoropyrimidines-DPYD, irinotecan-UGT1A1 and thiopurines-TPMT/NUDT15 were initially included. The current estimation of anticancer therapy doses usually does not reflect the complexities of metabolism. Therefore, efforts should be made in order to refine the ways we prescribe these drugs, being conventional cytotoxic or newer ones. This program is extremely welcome and may lead to more multi-institutional partnerships and should bring a broader discussion on the use of PGx and pharmacokinetics in routine oncology practice. |
| format | Article |
| id | doaj-art-b2c24ba1942041d5ac2c8d7b8a071d64 |
| institution | Kabale University |
| issn | 2526-8732 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-b2c24ba1942041d5ac2c8d7b8a071d642025-08-20T03:39:19ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322021-10-01170010.5935/2526-8732.20210003Pharmacogenomic tests in Oncology - finding the right doseJeziel Basso0Gilberto Schwartsmann1Programa de Pós-Graduação em Medicina: Ciências Médicas, Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, BrasilPrograma de Pós-Graduação em Medicina: Ciências Médicas, Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Porto Alegre, BrasilA pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA). Drug -gene pairs were selected for PGx testing based on the presence of clinically validated PGx associations and the availability of international guidelines with PGx-informed dosing recommendations. Fluoropyrimidines-DPYD, irinotecan-UGT1A1 and thiopurines-TPMT/NUDT15 were initially included. The current estimation of anticancer therapy doses usually does not reflect the complexities of metabolism. Therefore, efforts should be made in order to refine the ways we prescribe these drugs, being conventional cytotoxic or newer ones. This program is extremely welcome and may lead to more multi-institutional partnerships and should bring a broader discussion on the use of PGx and pharmacokinetics in routine oncology practice.http://www.brazilianjournalofoncology.com.br/details/153/en-US/pharmacogenomic-tests-in-oncology---finding-the-right-dosedpydfluoropyrimidinesirinotecannudt15pharmacogenomicsthiopurinestpmtugt1a1 |
| spellingShingle | Jeziel Basso Gilberto Schwartsmann Pharmacogenomic tests in Oncology - finding the right dose Brazilian Journal of Oncology dpyd fluoropyrimidines irinotecan nudt15 pharmacogenomics thiopurines tpmt ugt1a1 |
| title | Pharmacogenomic tests in Oncology - finding the right dose |
| title_full | Pharmacogenomic tests in Oncology - finding the right dose |
| title_fullStr | Pharmacogenomic tests in Oncology - finding the right dose |
| title_full_unstemmed | Pharmacogenomic tests in Oncology - finding the right dose |
| title_short | Pharmacogenomic tests in Oncology - finding the right dose |
| title_sort | pharmacogenomic tests in oncology finding the right dose |
| topic | dpyd fluoropyrimidines irinotecan nudt15 pharmacogenomics thiopurines tpmt ugt1a1 |
| url | http://www.brazilianjournalofoncology.com.br/details/153/en-US/pharmacogenomic-tests-in-oncology---finding-the-right-dose |
| work_keys_str_mv | AT jezielbasso pharmacogenomictestsinoncologyfindingtherightdose AT gilbertoschwartsmann pharmacogenomictestsinoncologyfindingtherightdose |