Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease
Abstract Adult neurogenesis is a complex multiphase process involving the formation and integration of new neurons into existing brain circuits. Although it was first described over 50 years ago and numerous factors involved in regulating neurogenic niches have been extensively studied, the underlyi...
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BMC
2025-07-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04430-2 |
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| author | Jannette Rodríguez-Pallares Lucia A. Garcia-Crivaro Juan A. Parga Jose Luis Labandeira-Garcia |
| author_facet | Jannette Rodríguez-Pallares Lucia A. Garcia-Crivaro Juan A. Parga Jose Luis Labandeira-Garcia |
| author_sort | Jannette Rodríguez-Pallares |
| collection | DOAJ |
| description | Abstract Adult neurogenesis is a complex multiphase process involving the formation and integration of new neurons into existing brain circuits. Although it was first described over 50 years ago and numerous factors involved in regulating neurogenic niches have been extensively studied, the underlying molecular mechanisms and interactions involved in controlling adult neurogenesis are still not fully understood. The renin-angiotensin system (RAS) is a well-known hormonal system that controls water and electrolyte balance and blood pressure. In addition to the circulating RAS, a local brain RAS has been described, with a key role in brain homeostasis. A wealth of evidence has emerged showing the involvement of RAS in neurodegeneration and neuroinflammation as well as in proliferation, differentiation, survival, and regeneration processes. Moreover, RAS has a role in cognitive function, behavioral responses, and dementia, which are closely related to neurogenic areas. This review summarizes the current evidence on the role of RAS in regulating adult neurogenic niches. We critically discuss pre-clinical and clinical studies investigating the role of RAS as a potential therapeutic target to modulate neurogenesis in pathological conditions. Graphical abstract |
| format | Article |
| id | doaj-art-b2bf0bf7c1c24626a517b72c5cfd6126 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-b2bf0bf7c1c24626a517b72c5cfd61262025-08-20T04:01:25ZengBMCStem Cell Research & Therapy1757-65122025-07-0116111510.1186/s13287-025-04430-2Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and diseaseJannette Rodríguez-Pallares0Lucia A. Garcia-Crivaro1Juan A. Parga2Jose Luis Labandeira-Garcia3Research Center for Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de CompostelaResearch Center for Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de CompostelaResearch Center for Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de CompostelaResearch Center for Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de CompostelaAbstract Adult neurogenesis is a complex multiphase process involving the formation and integration of new neurons into existing brain circuits. Although it was first described over 50 years ago and numerous factors involved in regulating neurogenic niches have been extensively studied, the underlying molecular mechanisms and interactions involved in controlling adult neurogenesis are still not fully understood. The renin-angiotensin system (RAS) is a well-known hormonal system that controls water and electrolyte balance and blood pressure. In addition to the circulating RAS, a local brain RAS has been described, with a key role in brain homeostasis. A wealth of evidence has emerged showing the involvement of RAS in neurodegeneration and neuroinflammation as well as in proliferation, differentiation, survival, and regeneration processes. Moreover, RAS has a role in cognitive function, behavioral responses, and dementia, which are closely related to neurogenic areas. This review summarizes the current evidence on the role of RAS in regulating adult neurogenic niches. We critically discuss pre-clinical and clinical studies investigating the role of RAS as a potential therapeutic target to modulate neurogenesis in pathological conditions. Graphical abstracthttps://doi.org/10.1186/s13287-025-04430-2Subependymal zoneSubgranular zoneHippocampusAngiotensinAT1 receptorsAT2 receptors |
| spellingShingle | Jannette Rodríguez-Pallares Lucia A. Garcia-Crivaro Juan A. Parga Jose Luis Labandeira-Garcia Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease Stem Cell Research & Therapy Subependymal zone Subgranular zone Hippocampus Angiotensin AT1 receptors AT2 receptors |
| title | Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| title_full | Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| title_fullStr | Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| title_full_unstemmed | Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| title_short | Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| title_sort | renin angiotensin system as an emerging target to modulate adult neurogenesis in health and disease |
| topic | Subependymal zone Subgranular zone Hippocampus Angiotensin AT1 receptors AT2 receptors |
| url | https://doi.org/10.1186/s13287-025-04430-2 |
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