Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier
Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown i...
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MDPI AG
2025-03-01
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| author | Arailym Amanzholkyzy Shynar Zhumagaliyeva Nurgul Sultanova Zharylkasyn Abilov Damira Ongalbek Elvira Donbayeva Aktoty Niyazbekova Zhazira Mukazhanova |
| author_facet | Arailym Amanzholkyzy Shynar Zhumagaliyeva Nurgul Sultanova Zharylkasyn Abilov Damira Ongalbek Elvira Donbayeva Aktoty Niyazbekova Zhazira Mukazhanova |
| author_sort | Arailym Amanzholkyzy |
| collection | DOAJ |
| description | Hydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown in hydrogels of cellulose ether derivatives due to the possibility of obtaining their modified forms to vary the solubility, the degree of prolonged action, and the release of the active substance, as well as their widespread availability, affordability, and the possibility of sourcing raw materials from different sources. Hydroxypropyl methylcellulose (HPMC, “hypromellose”) is one of the most popular cellulose ethers in the production of medicines as a filler, coating and carrier. Research on hydrogel carriers based on polymer complexes and modified forms of HPMC using acrylic, citric, and lactic acids, PVP, chitosan, Na-CMC, and gelatin is of particular interest, as they provide the necessary rheological and swelling characteristics. There is growing interest in medical transdermal hydrogels, films, capsules, membranes, nanocrystals, and nanofibers based on HPMC with the incorporation of biologically active substances (BASs), especially those of plant origin, as antibacterial, wound-healing, antimicrobial, mucoadhesive, anti-inflammatory, and antioxidant agents. The aim of this article is to review modern research and achievements in the field of hydrogel systems based on cellulose ethers, particularly HPMC, analyzing their properties, methods of production, and prospects for application in medicine and pharmacy. |
| format | Article |
| id | doaj-art-b2befc82a3294001a7095dca9fa597c2 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-b2befc82a3294001a7095dca9fa597c22025-08-20T01:49:05ZengMDPI AGMolecules1420-30492025-03-01306135410.3390/molecules30061354Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a CarrierArailym Amanzholkyzy0Shynar Zhumagaliyeva1Nurgul Sultanova2Zharylkasyn Abilov3Damira Ongalbek4Elvira Donbayeva5Aktoty Niyazbekova6Zhazira Mukazhanova7Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, KazakhstanDepartment of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, KazakhstanDepartment of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010000, KazakhstanDepartment of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, KazakhstanDepartment of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, KazakhstanDepartment of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010000, KazakhstanDepartment of Veterinary Science and Technosphere Safety, West Kazakhstan Innovation and Technological University, Uralsk 090009, KazakhstanHigher School of IT and Natural Sciences, S. Amanzholov East Kazakhstan University, Ust-Kamenogorsk 070010, KazakhstanHydrogel delivery systems are popular dosage forms that have a number of advantages, such as ease of use, painlessness, increased efficiency due to prolongation of rheological, swelling and sorption characteristics, regulation of drug release, and stimulus sensitivity. Particular interest is shown in hydrogels of cellulose ether derivatives due to the possibility of obtaining their modified forms to vary the solubility, the degree of prolonged action, and the release of the active substance, as well as their widespread availability, affordability, and the possibility of sourcing raw materials from different sources. Hydroxypropyl methylcellulose (HPMC, “hypromellose”) is one of the most popular cellulose ethers in the production of medicines as a filler, coating and carrier. Research on hydrogel carriers based on polymer complexes and modified forms of HPMC using acrylic, citric, and lactic acids, PVP, chitosan, Na-CMC, and gelatin is of particular interest, as they provide the necessary rheological and swelling characteristics. There is growing interest in medical transdermal hydrogels, films, capsules, membranes, nanocrystals, and nanofibers based on HPMC with the incorporation of biologically active substances (BASs), especially those of plant origin, as antibacterial, wound-healing, antimicrobial, mucoadhesive, anti-inflammatory, and antioxidant agents. The aim of this article is to review modern research and achievements in the field of hydrogel systems based on cellulose ethers, particularly HPMC, analyzing their properties, methods of production, and prospects for application in medicine and pharmacy.https://www.mdpi.com/1420-3049/30/6/1354hydrogelsplant extractscellulose derivativescellulose ethersdrug deliveryrelease |
| spellingShingle | Arailym Amanzholkyzy Shynar Zhumagaliyeva Nurgul Sultanova Zharylkasyn Abilov Damira Ongalbek Elvira Donbayeva Aktoty Niyazbekova Zhazira Mukazhanova Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier Molecules hydrogels plant extracts cellulose derivatives cellulose ethers drug delivery release |
| title | Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier |
| title_full | Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier |
| title_fullStr | Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier |
| title_full_unstemmed | Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier |
| title_short | Hydrogel Delivery Systems for Biological Active Substances: Properties and the Role of HPMC as a Carrier |
| title_sort | hydrogel delivery systems for biological active substances properties and the role of hpmc as a carrier |
| topic | hydrogels plant extracts cellulose derivatives cellulose ethers drug delivery release |
| url | https://www.mdpi.com/1420-3049/30/6/1354 |
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