Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis
Abstract The significant prevalence of periodontal diseases on the background of its tendency to increase makes the issue of search for early diagnostic methods and rational preventive therapeutic choice in generalized periodontitis to be topical. Purpose of the article is to determine the pro...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2018-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/141686/141123 |
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| author | O. O. Fastovets A. Yu. Lukash |
| author_facet | O. O. Fastovets A. Yu. Lukash |
| author_sort | O. O. Fastovets |
| collection | DOAJ |
| description | Abstract
The significant prevalence of periodontal diseases on the background of its tendency to increase makes the issue of search for early diagnostic methods and rational preventive therapeutic choice in generalized periodontitis to be topical.
Purpose of the article is to determine the prospects for matrix metalloproteinase-8 (MMP-8) using for early diagnosis of generalized periodontitis according to the modern literature analysis over the past two years. The review presents data on the biological properties of MMP-8, its role in the processes of collagen destruction and also shows the results of clinical and experimental studies devoted to clarifying the role of MMP-8 in the pathogenesis of generalized periodontitis. It is noted that this enzyme content is indicative of the gums inflammatory process transformation to the alveolar bone destruction; therefore it can be considered as the prognostic marker for generalized periodontitis, even in the absence of pronounced clinical symptoms. Moreover, the increase in MMP-8 activity indicates the aggressive form of the disease requiring specific treatment. Particular attention is given to MMP-8 as the biochemical marker describing the features of generalized periodontitis course, in particular on the background of comorbid diseases such as diabetes, rheumatoid arthritis and in smokers. The relationship between MMP-8 level and other biochemical markers (interleukins, immunoglobulins, prostaglandins) is described in inflammatory-dystrophic lesions of the periodontal tissues. The comparative evaluation of the MMP-8 modern methods of determination effectiveness in various biological fluids has been carried out. Prospects and peculiarities of MMP-8 using in diagnostics and treatment for peri-implantitis, which are similar in pathogenesis to periodontitis, have been defined.
Conclusions. It is worthwhile conducting the further studies of the MMP-8 possible use not only for the early diagnosis of generalized periodontitis, but also for its character prediction in order to develop the personal approach to patient care. Also, further studies in this direction will give an opportunity to move away from ambiguity and inconsistency in literature data and confirm the clinical effectiveness of MMP-8 for practical dentistry. |
| format | Article |
| id | doaj-art-b2bb152a52e2430aaaec20c06d135ae3 |
| institution | Kabale University |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-b2bb152a52e2430aaaec20c06d135ae32025-08-20T03:39:21ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102018-10-01572372810.14739/2310-1210.2018.5.141686Matrix metalloproteinase-8 in early diagnostics of generalized periodontitisO. O. Fastovets A. Yu. LukashAbstract The significant prevalence of periodontal diseases on the background of its tendency to increase makes the issue of search for early diagnostic methods and rational preventive therapeutic choice in generalized periodontitis to be topical. Purpose of the article is to determine the prospects for matrix metalloproteinase-8 (MMP-8) using for early diagnosis of generalized periodontitis according to the modern literature analysis over the past two years. The review presents data on the biological properties of MMP-8, its role in the processes of collagen destruction and also shows the results of clinical and experimental studies devoted to clarifying the role of MMP-8 in the pathogenesis of generalized periodontitis. It is noted that this enzyme content is indicative of the gums inflammatory process transformation to the alveolar bone destruction; therefore it can be considered as the prognostic marker for generalized periodontitis, even in the absence of pronounced clinical symptoms. Moreover, the increase in MMP-8 activity indicates the aggressive form of the disease requiring specific treatment. Particular attention is given to MMP-8 as the biochemical marker describing the features of generalized periodontitis course, in particular on the background of comorbid diseases such as diabetes, rheumatoid arthritis and in smokers. The relationship between MMP-8 level and other biochemical markers (interleukins, immunoglobulins, prostaglandins) is described in inflammatory-dystrophic lesions of the periodontal tissues. The comparative evaluation of the MMP-8 modern methods of determination effectiveness in various biological fluids has been carried out. Prospects and peculiarities of MMP-8 using in diagnostics and treatment for peri-implantitis, which are similar in pathogenesis to periodontitis, have been defined. Conclusions. It is worthwhile conducting the further studies of the MMP-8 possible use not only for the early diagnosis of generalized periodontitis, but also for its character prediction in order to develop the personal approach to patient care. Also, further studies in this direction will give an opportunity to move away from ambiguity and inconsistency in literature data and confirm the clinical effectiveness of MMP-8 for practical dentistry.http://zmj.zsmu.edu.ua/article/view/141686/141123periodontitismatrix metalloproteinase 8early diagnosis |
| spellingShingle | O. O. Fastovets A. Yu. Lukash Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis Zaporožskij Medicinskij Žurnal periodontitis matrix metalloproteinase 8 early diagnosis |
| title | Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis |
| title_full | Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis |
| title_fullStr | Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis |
| title_full_unstemmed | Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis |
| title_short | Matrix metalloproteinase-8 in early diagnostics of generalized periodontitis |
| title_sort | matrix metalloproteinase 8 in early diagnostics of generalized periodontitis |
| topic | periodontitis matrix metalloproteinase 8 early diagnosis |
| url | http://zmj.zsmu.edu.ua/article/view/141686/141123 |
| work_keys_str_mv | AT oofastovets matrixmetalloproteinase8inearlydiagnosticsofgeneralizedperiodontitis AT ayulukash matrixmetalloproteinase8inearlydiagnosticsofgeneralizedperiodontitis |