Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity

Abstract Radio-resistance of cancer stem-like cells (CSCs) is associated with the failure of radiation therapy. ZsGreen1-positive (ZsG⁺) cells, which exhibit low proteasome activity, have been used to enable the detection and isolation of CSCs. However, the mechanisms of radio-resistance in canine t...

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Bibliographic Details
Main Authors: Koangyong Sung, Kenji Hosoya, Tatsuya Deguchi, Koya Yamashita, Sangho Kim, Takafumi Sunaga, Hironobu Yasui, Osamu Inanami, Masahiro Okumura
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-02569-9
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