Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model

Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model

Abstract Objective To produce pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and culture and differentiate them into vascular organoids, producing a disease...

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Bibliographic Details
Main Authors: Zhiqiang Wang, Jianjian Yin, Wa Chao, Xiaoning Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Vascular organoids
Induced pluripotent stem cells
CADASIL
Cerebral small vessel disease
Online Access:https://doi.org/10.1186/s40001-025-02491-w
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