Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial
IntroductionSpinocerebellar ataxia type 3 (SCA3) poses challenges for patients due to motor dysfunctions and non-motor symptoms (NMS), such as sleep disorders, cognitive deficits, and mood disturbances. These issues significantly impact the quality of life, with limited benefits from conventional ph...
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Frontiers Media S.A.
2025-05-01
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| author | Hua Wu Hua Wu Hao-Ling Xu Xia-Hua Liu Arif Sikandar Wei Lin Mao-Lin Cui Ming-Xia Kang Ming-Xia Kang Yi-Ru Zheng Yi-Ru Zheng Shi-Rui Gan Shi-Rui Gan Liang-Liang Qiu Liang-Liang Qiu |
| author_facet | Hua Wu Hua Wu Hao-Ling Xu Xia-Hua Liu Arif Sikandar Wei Lin Mao-Lin Cui Ming-Xia Kang Ming-Xia Kang Yi-Ru Zheng Yi-Ru Zheng Shi-Rui Gan Shi-Rui Gan Liang-Liang Qiu Liang-Liang Qiu |
| author_sort | Hua Wu |
| collection | DOAJ |
| description | IntroductionSpinocerebellar ataxia type 3 (SCA3) poses challenges for patients due to motor dysfunctions and non-motor symptoms (NMS), such as sleep disorders, cognitive deficits, and mood disturbances. These issues significantly impact the quality of life, with limited benefits from conventional pharmacotherapies. This study explores the potential of repetitive transcranial magnetic stimulation (rTMS) as a treatment for SCA3-related NMS.MethodsThis is a secondary analysis of a randomized, double-blind, sham-controlled trial (The Chinese Clinical Trial Registry identifier is ChiCTR1800020133). Thirty-seven SCA3 patients included underwent either real (n = 21) or sham (n = 16) rTMS over 15 days, targeting the cerebellum. Study outcomes included the Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS), assessed baseline and post-intervention.ResultsThe results disclosed significant time effects for all the outcomes with post hoc comparisons showing differences of baseline and post-treatment evaluation, with decreases for PSQI, AIS, HARS, and HDRS as well as increase for MMSE and MoCA. Correlation analyses revealed no significant predictors of rTMS response based on age at onset, disease duration, number of expanded CAG repeat lengths, or baseline motor symptom severity scores.ConclusionRepetitive transcranial magnetic stimulation is a feasible treatment of non-motor related symptoms in patients with SCA3, including sleep, cognition, and mood disorders. The treatment is well-tolerated, and its feasibility appears independent of demographic or disease severity indicators. These findings encourage further exploration of rTMS as a safe alternative for managing SCA3 NMS. |
| format | Article |
| id | doaj-art-b2a5e4f220304e37ab9f2cbcd73ca177 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-b2a5e4f220304e37ab9f2cbcd73ca1772025-08-20T03:13:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15672921567292Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trialHua Wu0Hua Wu1Hao-Ling Xu2Xia-Hua Liu3Arif Sikandar4Wei Lin5Mao-Lin Cui6Ming-Xia Kang7Ming-Xia Kang8Yi-Ru Zheng9Yi-Ru Zheng10Shi-Rui Gan11Shi-Rui Gan12Liang-Liang Qiu13Liang-Liang Qiu14Department of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology and Institute of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaIntroductionSpinocerebellar ataxia type 3 (SCA3) poses challenges for patients due to motor dysfunctions and non-motor symptoms (NMS), such as sleep disorders, cognitive deficits, and mood disturbances. These issues significantly impact the quality of life, with limited benefits from conventional pharmacotherapies. This study explores the potential of repetitive transcranial magnetic stimulation (rTMS) as a treatment for SCA3-related NMS.MethodsThis is a secondary analysis of a randomized, double-blind, sham-controlled trial (The Chinese Clinical Trial Registry identifier is ChiCTR1800020133). Thirty-seven SCA3 patients included underwent either real (n = 21) or sham (n = 16) rTMS over 15 days, targeting the cerebellum. Study outcomes included the Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS), assessed baseline and post-intervention.ResultsThe results disclosed significant time effects for all the outcomes with post hoc comparisons showing differences of baseline and post-treatment evaluation, with decreases for PSQI, AIS, HARS, and HDRS as well as increase for MMSE and MoCA. Correlation analyses revealed no significant predictors of rTMS response based on age at onset, disease duration, number of expanded CAG repeat lengths, or baseline motor symptom severity scores.ConclusionRepetitive transcranial magnetic stimulation is a feasible treatment of non-motor related symptoms in patients with SCA3, including sleep, cognition, and mood disorders. The treatment is well-tolerated, and its feasibility appears independent of demographic or disease severity indicators. These findings encourage further exploration of rTMS as a safe alternative for managing SCA3 NMS.https://www.frontiersin.org/articles/10.3389/fneur.2025.1567292/fullrepetitive transcranial magnetic stimulation (rTMS)spinocerebellar ataxia type 3 (SCA3)non-motor symptoms (NMS)sleep disturbancecerebellumcognitive deficits |
| spellingShingle | Hua Wu Hua Wu Hao-Ling Xu Xia-Hua Liu Arif Sikandar Wei Lin Mao-Lin Cui Ming-Xia Kang Ming-Xia Kang Yi-Ru Zheng Yi-Ru Zheng Shi-Rui Gan Shi-Rui Gan Liang-Liang Qiu Liang-Liang Qiu Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial Frontiers in Neurology repetitive transcranial magnetic stimulation (rTMS) spinocerebellar ataxia type 3 (SCA3) non-motor symptoms (NMS) sleep disturbance cerebellum cognitive deficits |
| title | Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial |
| title_full | Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial |
| title_fullStr | Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial |
| title_full_unstemmed | Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial |
| title_short | Feasibility of repetitive transcranial magnetic stimulation on non-motor symptoms of spinocerebellar ataxia type 3: a secondary analysis of a randomized clinical trial |
| title_sort | feasibility of repetitive transcranial magnetic stimulation on non motor symptoms of spinocerebellar ataxia type 3 a secondary analysis of a randomized clinical trial |
| topic | repetitive transcranial magnetic stimulation (rTMS) spinocerebellar ataxia type 3 (SCA3) non-motor symptoms (NMS) sleep disturbance cerebellum cognitive deficits |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1567292/full |
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