The impact of varicella vaccination: A 2005–2019 interrupted time series analysis
Varicella is an acute, highly contagious disease in susceptible individuals and is preventable through vaccination. This study aimed to determine the impact of varicella vaccination on hospitalizations and complications at a pediatric reference hospital in Panama before and after the vaccine introdu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2023.2278927 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849472254761500672 |
|---|---|
| author | Katherina U. Miranda Rodrigo DeAntonio Ximena Norero Dora Estripeaut |
| author_facet | Katherina U. Miranda Rodrigo DeAntonio Ximena Norero Dora Estripeaut |
| author_sort | Katherina U. Miranda |
| collection | DOAJ |
| description | Varicella is an acute, highly contagious disease in susceptible individuals and is preventable through vaccination. This study aimed to determine the impact of varicella vaccination on hospitalizations and complications at a pediatric reference hospital in Panama before and after the vaccine introduction. This descriptive ecological study analyzed clinical records of patients diagnosed with varicella through a retrospective and interrupted time series analysis. An autoregressive integrated moving average model was built to compare the incidence rates observed after vaccination with those expected rates derived from the model. A statistical model was fitted to the observed interrupted time series data by regression and used to predict future trends. The mean difference in varicella hospital discharges before and after the introduction of the varicella vaccine was 47%. The rate of hospitalizations for varicella decreased to 52.3%. A declining trend in varicella hospitalizations was observed from 2015 after vaccine introduction in 2014. Complications in vaccinated patients were secondary skin and soft tissue infection, possibly due to bacterial superinfection. The impact of varicella vaccination on reducing varicella hospital discharges reported at a pediatric reference hospital in Panama was confirmed. |
| format | Article |
| id | doaj-art-b2a25c6326ea42928a40cddbca5dff3f |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-b2a25c6326ea42928a40cddbca5dff3f2025-08-20T03:24:35ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-12-0119310.1080/21645515.2023.2278927The impact of varicella vaccination: A 2005–2019 interrupted time series analysisKatherina U. Miranda0Rodrigo DeAntonio1Ximena Norero2Dora Estripeaut3Pediatric Infectious Diseases, Hospital José Domingo de Obaldía, Panama City, PanamaEpidemiology and Public Health, Centro de Investigación Cevaxin The Panama Clinic, Panama City, PanamaPediatric Infectious Diseases, Hospital del Niño José Renán Esquivel, Panama City, PanamaPediatric Infectious Diseases, Hospital del Niño José Renán Esquivel, Panama City, PanamaVaricella is an acute, highly contagious disease in susceptible individuals and is preventable through vaccination. This study aimed to determine the impact of varicella vaccination on hospitalizations and complications at a pediatric reference hospital in Panama before and after the vaccine introduction. This descriptive ecological study analyzed clinical records of patients diagnosed with varicella through a retrospective and interrupted time series analysis. An autoregressive integrated moving average model was built to compare the incidence rates observed after vaccination with those expected rates derived from the model. A statistical model was fitted to the observed interrupted time series data by regression and used to predict future trends. The mean difference in varicella hospital discharges before and after the introduction of the varicella vaccine was 47%. The rate of hospitalizations for varicella decreased to 52.3%. A declining trend in varicella hospitalizations was observed from 2015 after vaccine introduction in 2014. Complications in vaccinated patients were secondary skin and soft tissue infection, possibly due to bacterial superinfection. The impact of varicella vaccination on reducing varicella hospital discharges reported at a pediatric reference hospital in Panama was confirmed.https://www.tandfonline.com/doi/10.1080/21645515.2023.2278927Varicellavaccinationpediatricsinterrupted time seriesretrospectiveimpact |
| spellingShingle | Katherina U. Miranda Rodrigo DeAntonio Ximena Norero Dora Estripeaut The impact of varicella vaccination: A 2005–2019 interrupted time series analysis Human Vaccines & Immunotherapeutics Varicella vaccination pediatrics interrupted time series retrospective impact |
| title | The impact of varicella vaccination: A 2005–2019 interrupted time series analysis |
| title_full | The impact of varicella vaccination: A 2005–2019 interrupted time series analysis |
| title_fullStr | The impact of varicella vaccination: A 2005–2019 interrupted time series analysis |
| title_full_unstemmed | The impact of varicella vaccination: A 2005–2019 interrupted time series analysis |
| title_short | The impact of varicella vaccination: A 2005–2019 interrupted time series analysis |
| title_sort | impact of varicella vaccination a 2005 2019 interrupted time series analysis |
| topic | Varicella vaccination pediatrics interrupted time series retrospective impact |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2023.2278927 |
| work_keys_str_mv | AT katherinaumiranda theimpactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT rodrigodeantonio theimpactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT ximenanorero theimpactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT doraestripeaut theimpactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT katherinaumiranda impactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT rodrigodeantonio impactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT ximenanorero impactofvaricellavaccinationa20052019interruptedtimeseriesanalysis AT doraestripeaut impactofvaricellavaccinationa20052019interruptedtimeseriesanalysis |