Removal of endotoxin by reverse phase HPLC abolishes anti-endothelial cell activity of bacterially expressed plasminogen kringle 5

The success of recombinant protein expression/purification in Escherichia coli depends on a high-fidelity system rendering purified proteins free of confounding contaminants such as endotoxin. Here we report on the expression and purification of a cryptic plasminogen-derived domain, kringle 5, which...

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Bibliographic Details
Main Authors: Andrew Dudley, William McKinstry, David Thomas, James Best, Alicia Jenkins
Format: Article
Language:English
Published: Taylor & Francis Group 2003-10-01
Series:BioTechniques
Online Access:https://www.future-science.com/doi/10.2144/03354st02
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