Force overestimation during vascular occlusion is triggered by motor system inhibition
Abstract Low-intensity resistance exercise with vascular occlusion enhances human muscular strength by elevating neural drive to muscles, which is accompanied by the additional activation of fast-twitch fibers because of muscle fatigue. However, few previous studies have investigated the underlying...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-93193-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850039936818872320 |
|---|---|
| author | Yudai Takarada Daichi Nozaki |
| author_facet | Yudai Takarada Daichi Nozaki |
| author_sort | Yudai Takarada |
| collection | DOAJ |
| description | Abstract Low-intensity resistance exercise with vascular occlusion enhances human muscular strength by elevating neural drive to muscles, which is accompanied by the additional activation of fast-twitch fibers because of muscle fatigue. However, few previous studies have investigated the underlying neuromotor mechanisms from a perspective other than muscle fatigue. Notably, participants require more voluntary effort to exert muscular force to lift a weight immediately after vascular occlusion, indicating its acute effect on the force perception system without muscle fatigue. However, the major cause of force overestimation under these conditions remains unclear. We sought to elucidate the neural mechanism of force exertion combined with tourniquet-induced vascular occlusion, with special reference to exerted force perception, using motor evoked potentials in response to transcranial magnetic stimulation applied over the contralateral primary motor cortex as well as upper extremity H-reflex measurements. Rapid force overestimation was accompanied by the instantaneous inhibition of spinal motoneuron and corticospinal tract excitability. Thus, force overestimation may be caused by motor-related cortical areas functioning as the source of excitatory input to the corticospinal tract; participants would be unable to exert the same handgrip force as with normal blood flow without a compensatory input to the corticospinal tract from motor-related cortical areas. |
| format | Article |
| id | doaj-art-b29be135609c43d98666ad7f5d2178e8 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b29be135609c43d98666ad7f5d2178e82025-08-20T02:56:12ZengNature PortfolioScientific Reports2045-23222025-03-0115111810.1038/s41598-025-93193-0Force overestimation during vascular occlusion is triggered by motor system inhibitionYudai Takarada0Daichi Nozaki1Faculty of Sports Sciences, Waseda UniversityGraduate School of Education, The University of TokyoAbstract Low-intensity resistance exercise with vascular occlusion enhances human muscular strength by elevating neural drive to muscles, which is accompanied by the additional activation of fast-twitch fibers because of muscle fatigue. However, few previous studies have investigated the underlying neuromotor mechanisms from a perspective other than muscle fatigue. Notably, participants require more voluntary effort to exert muscular force to lift a weight immediately after vascular occlusion, indicating its acute effect on the force perception system without muscle fatigue. However, the major cause of force overestimation under these conditions remains unclear. We sought to elucidate the neural mechanism of force exertion combined with tourniquet-induced vascular occlusion, with special reference to exerted force perception, using motor evoked potentials in response to transcranial magnetic stimulation applied over the contralateral primary motor cortex as well as upper extremity H-reflex measurements. Rapid force overestimation was accompanied by the instantaneous inhibition of spinal motoneuron and corticospinal tract excitability. Thus, force overestimation may be caused by motor-related cortical areas functioning as the source of excitatory input to the corticospinal tract; participants would be unable to exert the same handgrip force as with normal blood flow without a compensatory input to the corticospinal tract from motor-related cortical areas.https://doi.org/10.1038/s41598-025-93193-0 |
| spellingShingle | Yudai Takarada Daichi Nozaki Force overestimation during vascular occlusion is triggered by motor system inhibition Scientific Reports |
| title | Force overestimation during vascular occlusion is triggered by motor system inhibition |
| title_full | Force overestimation during vascular occlusion is triggered by motor system inhibition |
| title_fullStr | Force overestimation during vascular occlusion is triggered by motor system inhibition |
| title_full_unstemmed | Force overestimation during vascular occlusion is triggered by motor system inhibition |
| title_short | Force overestimation during vascular occlusion is triggered by motor system inhibition |
| title_sort | force overestimation during vascular occlusion is triggered by motor system inhibition |
| url | https://doi.org/10.1038/s41598-025-93193-0 |
| work_keys_str_mv | AT yudaitakarada forceoverestimationduringvascularocclusionistriggeredbymotorsysteminhibition AT daichinozaki forceoverestimationduringvascularocclusionistriggeredbymotorsysteminhibition |