Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, significantly impacting their quality of life. AMD is classified into two main types: dry (non-neovascular) and wet (neovascular) AMD. While the dry form is more prevalent, the wet form is associated with more...
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Mashhad University of Medical Sciences
2025-03-01
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| Series: | Reviews in Clinical Medicine |
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| Online Access: | https://rcm.mums.ac.ir/article_25711_cb384bf3b255e5aebb4d144e97103d3d.pdf |
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| author | Mehrdad Motamed Shariati |
| author_facet | Mehrdad Motamed Shariati |
| author_sort | Mehrdad Motamed Shariati |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, significantly impacting their quality of life. AMD is classified into two main types: dry (non-neovascular) and wet (neovascular) AMD. While the dry form is more prevalent, the wet form is associated with more severe vision impairment. The variability of AMD, influenced by genetic, environmental, and lifestyle factors, presents a significant challenge in its management. Precision medicine, which tailors healthcare according to individual differences, has emerged as a promising approach for diagnosing, treating, and preventing AMD. This represents a paradigm shift in the management of AMD. By customizing treatments based on individual genetic, environmental, and lifestyle factors, precision medicine can potentially improve outcomes for AMD patients. This review comprehensively evaluates current precision medicine strategies in AMD, addresses existing challenges, and explores the potential for personalized interventions to enhance patient outcomes. |
| format | Article |
| id | doaj-art-b29a23facd914ccca9e6b61291a2688a |
| institution | OA Journals |
| issn | 2345-6256 2345-6892 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj-art-b29a23facd914ccca9e6b61291a2688a2025-08-20T02:08:31ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922025-03-01121273110.22038/rcm.2025.81807.150325711Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future DirectionsMehrdad Motamed Shariati0Eye Research Center, Mashhad University of Medical Sciences, Mashhad, IranAge-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, significantly impacting their quality of life. AMD is classified into two main types: dry (non-neovascular) and wet (neovascular) AMD. While the dry form is more prevalent, the wet form is associated with more severe vision impairment. The variability of AMD, influenced by genetic, environmental, and lifestyle factors, presents a significant challenge in its management. Precision medicine, which tailors healthcare according to individual differences, has emerged as a promising approach for diagnosing, treating, and preventing AMD. This represents a paradigm shift in the management of AMD. By customizing treatments based on individual genetic, environmental, and lifestyle factors, precision medicine can potentially improve outcomes for AMD patients. This review comprehensively evaluates current precision medicine strategies in AMD, addresses existing challenges, and explores the potential for personalized interventions to enhance patient outcomes.https://rcm.mums.ac.ir/article_25711_cb384bf3b255e5aebb4d144e97103d3d.pdfstratified medicineage-related macular degenerationgenetic biomarkerspersonalized therapeuticsproteomics |
| spellingShingle | Mehrdad Motamed Shariati Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions Reviews in Clinical Medicine stratified medicine age-related macular degeneration genetic biomarkers personalized therapeutics proteomics |
| title | Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions |
| title_full | Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions |
| title_fullStr | Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions |
| title_full_unstemmed | Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions |
| title_short | Precision Medicine in Age-Related Macular Degeneration: Current Approaches and Future Directions |
| title_sort | precision medicine in age related macular degeneration current approaches and future directions |
| topic | stratified medicine age-related macular degeneration genetic biomarkers personalized therapeutics proteomics |
| url | https://rcm.mums.ac.ir/article_25711_cb384bf3b255e5aebb4d144e97103d3d.pdf |
| work_keys_str_mv | AT mehrdadmotamedshariati precisionmedicineinagerelatedmaculardegenerationcurrentapproachesandfuturedirections |