Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men
We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/293916 |
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| author | Katherine Esposito Carmen Di Palo Maria Ida Maiorino Michela Petrizzo Giuseppe Bellastella Isabella Siniscalchi Dario Giugliano |
| author_facet | Katherine Esposito Carmen Di Palo Maria Ida Maiorino Michela Petrizzo Giuseppe Bellastella Isabella Siniscalchi Dario Giugliano |
| author_sort | Katherine Esposito |
| collection | DOAJ |
| description | We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was −14 kg (95% CI −20 to −8) in lifestyle groups and −2.0 kg (−4.4 to 0) in the advice groups, with a difference of −11.9 kg (CI −19 to −4.7 kg, 𝑃<.001); moreover, there was a significant difference between groups at 2 years for insulin (𝑃=.04), 8-iso-PGF2α (𝑃=.037), glucose (𝑃=.04), and adiponectin (𝑃=.01). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity. |
| format | Article |
| id | doaj-art-b29637ac707c46e7858b616f225a6cd5 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-b29637ac707c46e7858b616f225a6cd52025-02-03T01:26:30ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/293916293916Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight MenKatherine Esposito0Carmen Di Palo1Maria Ida Maiorino2Michela Petrizzo3Giuseppe Bellastella4Isabella Siniscalchi5Dario Giugliano6Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyChair and Division of Metabolic Diseases, Second University of Naples, Piazza L. Miraglia, 80138 Napoli, ItalyWe report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was −14 kg (95% CI −20 to −8) in lifestyle groups and −2.0 kg (−4.4 to 0) in the advice groups, with a difference of −11.9 kg (CI −19 to −4.7 kg, 𝑃<.001); moreover, there was a significant difference between groups at 2 years for insulin (𝑃=.04), 8-iso-PGF2α (𝑃=.037), glucose (𝑃=.04), and adiponectin (𝑃=.01). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity.http://dx.doi.org/10.4061/2011/293916 |
| spellingShingle | Katherine Esposito Carmen Di Palo Maria Ida Maiorino Michela Petrizzo Giuseppe Bellastella Isabella Siniscalchi Dario Giugliano Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men Cardiology Research and Practice |
| title | Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men |
| title_full | Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men |
| title_fullStr | Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men |
| title_full_unstemmed | Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men |
| title_short | Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men |
| title_sort | long term effect of mediterranean style diet and calorie restriction on biomarkers of longevity and oxidative stress in overweight men |
| url | http://dx.doi.org/10.4061/2011/293916 |
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