A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection

Abstract Background Leishmania infantum is the only prevalent Leishmania species in Europe and manifesting predominantly as cutaneous or visceral leishmaniasis, whereas new world species like Leishmania (L.) braziliensis are well known pathogens in mucocutaneous leishmaniasis. Mucosal leishmaniasis...

Full description

Saved in:
Bibliographic Details
Main Authors: Yannik Eggers, Martha Holtfreter, Irmela Müller-Stoever, Johannes Mischlinger, Andreas Hammacher, Bernhard Hemmerlein, Alexander Kreuter, Frank Oellig, Dennis Tappe, Tom Luedde, Torsten Feldt, Hans Martin Orth
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Infectious Diseases
Subjects:
Online Access:https://doi.org/10.1186/s12879-025-10592-4
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850190822825263104
author Yannik Eggers
Martha Holtfreter
Irmela Müller-Stoever
Johannes Mischlinger
Andreas Hammacher
Bernhard Hemmerlein
Alexander Kreuter
Frank Oellig
Dennis Tappe
Tom Luedde
Torsten Feldt
Hans Martin Orth
author_facet Yannik Eggers
Martha Holtfreter
Irmela Müller-Stoever
Johannes Mischlinger
Andreas Hammacher
Bernhard Hemmerlein
Alexander Kreuter
Frank Oellig
Dennis Tappe
Tom Luedde
Torsten Feldt
Hans Martin Orth
author_sort Yannik Eggers
collection DOAJ
description Abstract Background Leishmania infantum is the only prevalent Leishmania species in Europe and manifesting predominantly as cutaneous or visceral leishmaniasis, whereas new world species like Leishmania (L.) braziliensis are well known pathogens in mucocutaneous leishmaniasis. Mucosal leishmaniasis caused by L. infantum is a rare clinical condition with only few cases described in literature. In contrast to our case, mostly immunocompromised patients with no history of leishmaniasis are affected. Case presentation We describe the case of a 77-year-old German male who developed an ulcerous lesion of the tongue. As oral cancer was suspected, the patient underwent surgery. After suspected diagnosis of Leishmania spp. in histopathology, the patient was referred to our department for further diagnostics and treatment. Relapse from a cutaneous leishmaniasis acquired in Spain is likely, as L. infantum could be identified as the causative agent. The patient recovered after treatment. Conclusions Mucosal leishmaniasis caused by L. infantum is rare and usually mistaken for malignancy. As demonstrated, it can be preceded by cutaneous leishmaniasis of the immunocompetent. Due to possible dissemination systemic treatment should be applied.
format Article
id doaj-art-b292c86e09cd48018974052f1dced437
institution OA Journals
issn 1471-2334
language English
publishDate 2025-02-01
publisher BMC
record_format Article
series BMC Infectious Diseases
spelling doaj-art-b292c86e09cd48018974052f1dced4372025-08-20T02:15:08ZengBMCBMC Infectious Diseases1471-23342025-02-012511710.1186/s12879-025-10592-4A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infectionYannik Eggers0Martha Holtfreter1Irmela Müller-Stoever2Johannes Mischlinger3Andreas Hammacher4Bernhard Hemmerlein5Alexander Kreuter6Frank Oellig7Dennis Tappe8Tom Luedde9Torsten Feldt10Hans Martin Orth11Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfCenter for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine University Medical Center Hamburg-EppendorfKlinik für Mund-, Kiefer- und Gesichtschirurgie, Helios Klinikum Duisburg-HombergInstitut für Pathologie, Helios Klinikum KrefeldKlinik für Dermatologie, Venerologie und Allergologie, Helios St. Elisabeth Klinik Oberhausen, Universität Witten/HerdeckeInstitut für PathologieBernhard-Nocht-Institute for Tropical MedicineDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfDepartment of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty University Hospital Düsseldorf, Heinrich-Heine-University DüsseldorfAbstract Background Leishmania infantum is the only prevalent Leishmania species in Europe and manifesting predominantly as cutaneous or visceral leishmaniasis, whereas new world species like Leishmania (L.) braziliensis are well known pathogens in mucocutaneous leishmaniasis. Mucosal leishmaniasis caused by L. infantum is a rare clinical condition with only few cases described in literature. In contrast to our case, mostly immunocompromised patients with no history of leishmaniasis are affected. Case presentation We describe the case of a 77-year-old German male who developed an ulcerous lesion of the tongue. As oral cancer was suspected, the patient underwent surgery. After suspected diagnosis of Leishmania spp. in histopathology, the patient was referred to our department for further diagnostics and treatment. Relapse from a cutaneous leishmaniasis acquired in Spain is likely, as L. infantum could be identified as the causative agent. The patient recovered after treatment. Conclusions Mucosal leishmaniasis caused by L. infantum is rare and usually mistaken for malignancy. As demonstrated, it can be preceded by cutaneous leishmaniasis of the immunocompetent. Due to possible dissemination systemic treatment should be applied.https://doi.org/10.1186/s12879-025-10592-4Mucosal leishmaniasisLeishmania InfantumTongueCutaneous leishmaniasisReactivation
spellingShingle Yannik Eggers
Martha Holtfreter
Irmela Müller-Stoever
Johannes Mischlinger
Andreas Hammacher
Bernhard Hemmerlein
Alexander Kreuter
Frank Oellig
Dennis Tappe
Tom Luedde
Torsten Feldt
Hans Martin Orth
A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
BMC Infectious Diseases
Mucosal leishmaniasis
Leishmania Infantum
Tongue
Cutaneous leishmaniasis
Reactivation
title A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
title_full A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
title_fullStr A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
title_full_unstemmed A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
title_short A rare case of lingual mucosal leishmaniasis caused by reactivation of Leishmania infantum infection
title_sort rare case of lingual mucosal leishmaniasis caused by reactivation of leishmania infantum infection
topic Mucosal leishmaniasis
Leishmania Infantum
Tongue
Cutaneous leishmaniasis
Reactivation
url https://doi.org/10.1186/s12879-025-10592-4
work_keys_str_mv AT yannikeggers ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT marthaholtfreter ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT irmelamullerstoever ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT johannesmischlinger ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT andreashammacher ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT bernhardhemmerlein ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT alexanderkreuter ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT frankoellig ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT dennistappe ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT tomluedde ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT torstenfeldt ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT hansmartinorth ararecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT yannikeggers rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT marthaholtfreter rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT irmelamullerstoever rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT johannesmischlinger rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT andreashammacher rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT bernhardhemmerlein rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT alexanderkreuter rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT frankoellig rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT dennistappe rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT tomluedde rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT torstenfeldt rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection
AT hansmartinorth rarecaseoflingualmucosalleishmaniasiscausedbyreactivationofleishmaniainfantuminfection