Acquired cystic disease and renal cell carcinoma in hemodialysis patients: A case report on three patients
Introduction. Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and represents approximately 3.8% of all malignancies in adults. The incidence of renal cell carcinoma has been growing steadily and ranging from 0.6 to 14.7 for every 100,000 inhabitants. Patients with...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500027M.pdf |
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| Summary: | Introduction. Renal cell carcinoma (RCC) is derived from renal tubular
epithelial cells and represents approximately 3.8% of all malignancies in
adults. The incidence of renal cell carcinoma has been growing steadily and
ranging from 0.6 to 14.7 for every 100,000 inhabitants. Patients with
end-stage renal disease and acquired cystic kidney disease are at increased
risk of developing RCC while undergoing dialysis treatment or after renal
transplantation. Case report. We presented 3 patients undergoing
hemodialysis, with acquired cystic kidney disease accompanied by the
development of RCC. In all the patients tumor was asymptomatic and discovered
through ultrasound screening in 2 patients and in 1 of the patients by
post-surgery pathohistological analysis of the tissue of the kidney excised
using nephrectomy. All the three patients had organ-limited disease at the
time of the diagnosis and they did not require additional therapy after
surgical treatment. During the follow- up after nephrectomy from 6 months to
7 years, local recurrence or metastasis of RCC were not diagnosed.
Conclusion. Acquired cystic kidney disease represents a predisposing factor
for the development of renal cell carcinoma in dialysis patients and requires
regular ultrasound examinations of the abdomen aimed at early diagnosis of
malignancies. Prognosis for patients with endstage renal disease and RCC is
mostly good because these tumors are usually of indolent course. |
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| ISSN: | 0042-8450 2406-0720 |