MicroRNA in intestinal tight junction regulation
Abstract MicroRNAs are essential molecules that regulate many biological functions, including intestinal tight junction (TJ) barriers. They regulate pro-inflammatory cytokines, which increase TJ permeability, and anti-inflammatory cytokines, which protect against inflammation and promote intestinal...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | npj Gut and Liver |
| Online Access: | https://doi.org/10.1038/s44355-025-00022-2 |
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| Summary: | Abstract MicroRNAs are essential molecules that regulate many biological functions, including intestinal tight junction (TJ) barriers. They regulate pro-inflammatory cytokines, which increase TJ permeability, and anti-inflammatory cytokines, which protect against inflammation and promote intestinal balance. This review explores the role of miRNAs in controlling inflammation and as a potential therapeutic approach for treating IBD and other intestinal disorders. Circulating miRNAs can also serve as biomarkers for intestinal damage and disease progression. |
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| ISSN: | 3004-9806 |