Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Abstract Transportin 3 (TNPO3) is a nuclear import receptor known for its broad substrate specificity, often recognizing arginine-serine (SR/RS) repeat-rich nuclear localization signals (NLS) in SRSF proteins. While serine phosphorylation or glutamate presence has been associated with these NLSs, re...

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Bibliographic Details
Main Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59802-2
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