Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate
Joint endoprosthetics is a treatment of choice for patients with decompensated osteoarthritis (OA), who have exhausted the possibilities of pharmacotherapy and other methods of conservative treatment. Preparation for endoprosthetics and rehabilitation after surgery usually includes measures to impro...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-04-01
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| Series: | Фармакоэкономика |
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| Online Access: | https://www.pharmacoeconomics.ru/jour/article/view/665 |
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| author | I. Yu. Torshin T. B. Minasov N. V. Zagorodniy A. M. Lila O. A. Gromova |
| author_facet | I. Yu. Torshin T. B. Minasov N. V. Zagorodniy A. M. Lila O. A. Gromova |
| author_sort | I. Yu. Torshin |
| collection | DOAJ |
| description | Joint endoprosthetics is a treatment of choice for patients with decompensated osteoarthritis (OA), who have exhausted the possibilities of pharmacotherapy and other methods of conservative treatment. Preparation for endoprosthetics and rehabilitation after surgery usually includes measures to improve the muscle condition and local blood circulation in the joint area, and if necessary, pain management. The unique spectrum of anti-inflammatory effect of chondroprotectors based on chondroitin sulfate and glucosamine sulfate includes inhibition of NF-κB cascade, toll-like receptors, pro-inflammatory cytokines, metalloproteinases, and significantly alleviates the course of OA. Reducing the severity of OA is important for preparing for surgery, subsequent rehabilitation, and preventing the revision surgery. |
| format | Article |
| id | doaj-art-b28bc75492a041578e7c70dd408bcef5 |
| institution | DOAJ |
| issn | 2070-4909 2070-4933 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Фармакоэкономика |
| spelling | doaj-art-b28bc75492a041578e7c70dd408bcef52025-08-20T02:58:54ZrusIRBIS LLCФармакоэкономика2070-49092070-49332022-04-0115116216910.17749/2070-4909/farmakoekonomika.2022.136387Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfateI. Yu. Torshin0T. B. Minasov1N. V. Zagorodniy2A. M. Lila3O. A. Gromova4Federal Research Center “Informatics and Management”, Russian Academy of SciencesBashkir State Medical UniversityPriorov National Medical Research Center of Traumatology and Orthopedics; Peoples' Friendship University of RussiaNasonova Research Institute of RheumatologyFederal Research Center “Informatics and Management”, Russian Academy of SciencesJoint endoprosthetics is a treatment of choice for patients with decompensated osteoarthritis (OA), who have exhausted the possibilities of pharmacotherapy and other methods of conservative treatment. Preparation for endoprosthetics and rehabilitation after surgery usually includes measures to improve the muscle condition and local blood circulation in the joint area, and if necessary, pain management. The unique spectrum of anti-inflammatory effect of chondroprotectors based on chondroitin sulfate and glucosamine sulfate includes inhibition of NF-κB cascade, toll-like receptors, pro-inflammatory cytokines, metalloproteinases, and significantly alleviates the course of OA. Reducing the severity of OA is important for preparing for surgery, subsequent rehabilitation, and preventing the revision surgery.https://www.pharmacoeconomics.ru/jour/article/view/665joint endoprostheticspreoperative periodpostoperative rehabilitationosteoarthritischondroprotectionchondroitin sulfateglucosamine sulfate |
| spellingShingle | I. Yu. Torshin T. B. Minasov N. V. Zagorodniy A. M. Lila O. A. Gromova Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate Фармакоэкономика joint endoprosthetics preoperative period postoperative rehabilitation osteoarthritis chondroprotection chondroitin sulfate glucosamine sulfate |
| title | Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate |
| title_full | Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate |
| title_fullStr | Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate |
| title_full_unstemmed | Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate |
| title_short | Perioperative pharmacotherapy for endoprosthetics: potential of chondroitin sulfate and glucosamine sulfate |
| title_sort | perioperative pharmacotherapy for endoprosthetics potential of chondroitin sulfate and glucosamine sulfate |
| topic | joint endoprosthetics preoperative period postoperative rehabilitation osteoarthritis chondroprotection chondroitin sulfate glucosamine sulfate |
| url | https://www.pharmacoeconomics.ru/jour/article/view/665 |
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