Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases
The gut mucosa is an extension of the oral mucosa, and both are directly linked. There is emerging evidence that pathogenic oral microbiome contributes greatly to the risk of developing Inflammatory Bowel Disease (IBD). Dysbiosis of the oral microbiota can interfere with the host immune system'...
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| Format: | Article |
| Language: | English |
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Springer
2023-01-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905222001687 |
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| author | Hanan Balto Solaiman Al-Hadlaq Abdulmalik Alhadlaq Afaf El-Ansary |
| author_facet | Hanan Balto Solaiman Al-Hadlaq Abdulmalik Alhadlaq Afaf El-Ansary |
| author_sort | Hanan Balto |
| collection | DOAJ |
| description | The gut mucosa is an extension of the oral mucosa, and both are directly linked. There is emerging evidence that pathogenic oral microbiome contributes greatly to the risk of developing Inflammatory Bowel Disease (IBD). Dysbiosis of the oral microbiota can interfere with the host immune system's ability to respond normally, thereby increasing the development of periodontitis which raises the risk of IBD, cancer, rheumatoid arthritis, cardiovascular disease, and other complex disease processes. Salivary biomarkers are possibly important for determining the incidence, severity, and remission of IBD. Nevertheless, clinical translation of biomarker knowledge from lab to clinical practice needs further studies that identify biomarkers related to the transitional phase between healthy and unhealthy. In this review, the bidirectional pathway between the gut and the oral cavity was investigated and several aspects were discussed. |
| format | Article |
| id | doaj-art-b2873eb887744d348b4a1b1cbb85c29f |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-b2873eb887744d348b4a1b1cbb85c29f2025-08-20T03:04:30ZengSpringerSaudi Dental Journal1013-90522023-01-01351243010.1016/j.sdentj.2022.12.006Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseasesHanan Balto0Solaiman Al-Hadlaq1Abdulmalik Alhadlaq2Afaf El-Ansary3Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia; Central Research Laboratory, Female Campus, King Saud University, Riyadh, Saudi ArabiaDepartment of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia; Corresponding author.King Saud Medical City, Riyadh, Saudi ArabiaCentral Research Laboratory, Female Campus, King Saud University, Riyadh, Saudi ArabiaThe gut mucosa is an extension of the oral mucosa, and both are directly linked. There is emerging evidence that pathogenic oral microbiome contributes greatly to the risk of developing Inflammatory Bowel Disease (IBD). Dysbiosis of the oral microbiota can interfere with the host immune system's ability to respond normally, thereby increasing the development of periodontitis which raises the risk of IBD, cancer, rheumatoid arthritis, cardiovascular disease, and other complex disease processes. Salivary biomarkers are possibly important for determining the incidence, severity, and remission of IBD. Nevertheless, clinical translation of biomarker knowledge from lab to clinical practice needs further studies that identify biomarkers related to the transitional phase between healthy and unhealthy. In this review, the bidirectional pathway between the gut and the oral cavity was investigated and several aspects were discussed.http://www.sciencedirect.com/science/article/pii/S1013905222001687Gut microbiotaOral microbiotaDysbiosisPeriodontitisSalivary biomarkers |
| spellingShingle | Hanan Balto Solaiman Al-Hadlaq Abdulmalik Alhadlaq Afaf El-Ansary Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases Saudi Dental Journal Gut microbiota Oral microbiota Dysbiosis Periodontitis Salivary biomarkers |
| title | Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| title_full | Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| title_fullStr | Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| title_full_unstemmed | Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| title_short | Gum-gut axis: The potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| title_sort | gum gut axis the potential role of salivary biomarkers in the diagnosis and monitoring progress of inflammatory bowel diseases |
| topic | Gut microbiota Oral microbiota Dysbiosis Periodontitis Salivary biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S1013905222001687 |
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