A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp
OBJECTIVES: Achromobacter spp. are aerobic, non-fermentative gram-negative bacteria. These are the causative pathogens of healthcare-associated infections in patients who are hospitalized for long periods, undergone invasive procedures, and are immunocompromised. We present seven confirmed cases of...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524004004 |
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| author | Elif DEDE Neslihan Mete Atasever Mavera Uşaklıoğlu Erol Behiye Benaygul Kacmaz Öznur Bulut Burçak Akar AYPER SOMER Bahar AKGÜN KARAPINAR Betigul Ongen Selda Hançerli Törün |
| author_facet | Elif DEDE Neslihan Mete Atasever Mavera Uşaklıoğlu Erol Behiye Benaygul Kacmaz Öznur Bulut Burçak Akar AYPER SOMER Bahar AKGÜN KARAPINAR Betigul Ongen Selda Hançerli Törün |
| author_sort | Elif DEDE |
| collection | DOAJ |
| description | OBJECTIVES: Achromobacter spp. are aerobic, non-fermentative gram-negative bacteria. These are the causative pathogens of healthcare-associated infections in patients who are hospitalized for long periods, undergone invasive procedures, and are immunocompromised. We present seven confirmed cases of Achromobacter which is rarely a disease agent. METHODS: Clinical symptoms, laboratory test results and treatments of six cases of Achromobacter infections between January-2021 and June-2024 were analyzed retrospectively. RESULTS: Five of the patients (71.4%) were female and two were male. All patients had comorbidities [renal disease (n=2), and one patient each: cardiac disease, metabolic disease, neuroblastoma, liver transplant and factor 7 deficiency]. The hospital stay was >3 weeks in five (71.4%) patients. Four patients (57%) had central venous catheters(CVCs).Five of the growths were in blood culture (Bactec FX; Becton Dickinson-USA) and two in urine culture. The isolates were identified with the VITEK 2 Compact system and MALDI-TOF MS(bioMérieux-France). Achromobacter denitrificans growth was detected in three cases (two were from blood, one from urine) and Achromobacter xylosoxidas growth in the others.A meropenem-resistant strain was detected in the culture of a 7-year-old girl only with a diagnosis of recurrent neuroblastoma in septic shock. This patient was treated with colistin. Six of the strains obtained from other patients were susceptible to meropenem, five to piperacillin-tazobactam and trimethoprim-sulfamethoxazole. These patients were treated with meropenem and their CVC was removed. No mortality was observed. CONCLUSION: Although Achromobacter is a rare cause of hospital-acquired infection, it should be kept in mind in patients with prolonged hospital stays and those undergoing invasive procedures. |
| format | Article |
| id | doaj-art-b282d165df58439c9921f4aed3a8c992 |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-b282d165df58439c9921f4aed3a8c9922025-08-20T02:40:40ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-0139697010.1016/j.jgar.2024.10.223A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter SppElif DEDE0Neslihan Mete Atasever1Mavera Uşaklıoğlu Erol2Behiye Benaygul Kacmaz3Öznur Bulut4Burçak Akar5AYPER SOMER6Bahar AKGÜN KARAPINAR7Betigul Ongen8Selda Hançerli Törün9Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Istanbul, TurkeyIstanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, TurkeyOBJECTIVES: Achromobacter spp. are aerobic, non-fermentative gram-negative bacteria. These are the causative pathogens of healthcare-associated infections in patients who are hospitalized for long periods, undergone invasive procedures, and are immunocompromised. We present seven confirmed cases of Achromobacter which is rarely a disease agent. METHODS: Clinical symptoms, laboratory test results and treatments of six cases of Achromobacter infections between January-2021 and June-2024 were analyzed retrospectively. RESULTS: Five of the patients (71.4%) were female and two were male. All patients had comorbidities [renal disease (n=2), and one patient each: cardiac disease, metabolic disease, neuroblastoma, liver transplant and factor 7 deficiency]. The hospital stay was >3 weeks in five (71.4%) patients. Four patients (57%) had central venous catheters(CVCs).Five of the growths were in blood culture (Bactec FX; Becton Dickinson-USA) and two in urine culture. The isolates were identified with the VITEK 2 Compact system and MALDI-TOF MS(bioMérieux-France). Achromobacter denitrificans growth was detected in three cases (two were from blood, one from urine) and Achromobacter xylosoxidas growth in the others.A meropenem-resistant strain was detected in the culture of a 7-year-old girl only with a diagnosis of recurrent neuroblastoma in septic shock. This patient was treated with colistin. Six of the strains obtained from other patients were susceptible to meropenem, five to piperacillin-tazobactam and trimethoprim-sulfamethoxazole. These patients were treated with meropenem and their CVC was removed. No mortality was observed. CONCLUSION: Although Achromobacter is a rare cause of hospital-acquired infection, it should be kept in mind in patients with prolonged hospital stays and those undergoing invasive procedures.http://www.sciencedirect.com/science/article/pii/S2213716524004004{Achromobacter}childurinarybloodstreaminfection |
| spellingShingle | Elif DEDE Neslihan Mete Atasever Mavera Uşaklıoğlu Erol Behiye Benaygul Kacmaz Öznur Bulut Burçak Akar AYPER SOMER Bahar AKGÜN KARAPINAR Betigul Ongen Selda Hançerli Törün A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp Journal of Global Antimicrobial Resistance {Achromobacter} child urinary bloodstream infection |
| title | A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp |
| title_full | A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp |
| title_fullStr | A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp |
| title_full_unstemmed | A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp |
| title_short | A Rarely Cause Of Urinary And Bloodstream Infections: Achromobacter Spp |
| title_sort | rarely cause of urinary and bloodstream infections achromobacter spp |
| topic | {Achromobacter} child urinary bloodstream infection |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524004004 |
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