Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study
Objective. To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. Methods. Pregnancies > 16 week...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8245879 |
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| author | Sylvia J. Kroese Carolien N. H. Abheiden Birgit S. Blomjous Jacob M. van Laar Ronald W. H. M. Derksen Irene E. M. Bultink Alexandre E. Voskuyl A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries Ruth D. E. Fritsch-Stork |
| author_facet | Sylvia J. Kroese Carolien N. H. Abheiden Birgit S. Blomjous Jacob M. van Laar Ronald W. H. M. Derksen Irene E. M. Bultink Alexandre E. Voskuyl A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries Ruth D. E. Fritsch-Stork |
| author_sort | Sylvia J. Kroese |
| collection | DOAJ |
| description | Objective. To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. Methods. Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000 and 2015 were included. Disease activity, flare rate, and pregnancy outcomes and complications were assessed. Results. Ninety-six women (84% Caucasian) with 144 pregnancies were included. The median SLE(P)DAI score was 2 before, during, and after pregnancy. Flare rates were 6.3%, 20.1%, and 15.3%, respectively. Severe hypertensive disorder of pregnancy, intrauterine fetal death, preterm birth, and small-for-gestational age infants occurred in 18.1%, 4.1%, 32.7%, and 14.8%, respectively. Complication rates were similar in the first and consecutive pregnancies. Half of the women did not experience any pregnancy complication whereas 42.7% developed a complication during all pregnancies. Mean number of pregnancies was 2.4 and live births 1.7. Conclusion. In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling. |
| format | Article |
| id | doaj-art-b27c7ed42ac04b75b71d22159bff198f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b27c7ed42ac04b75b71d22159bff198f2025-02-03T01:30:04ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/82458798245879Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort StudySylvia J. Kroese0Carolien N. H. Abheiden1Birgit S. Blomjous2Jacob M. van Laar3Ronald W. H. M. Derksen4Irene E. M. Bultink5Alexandre E. Voskuyl6A. Titia Lely7Marjon A. de Boer8Johanna I. P. de Vries9Ruth D. E. Fritsch-Stork10Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, NetherlandsDepartment of Obstetrics and Gynecology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Obstetrics and Gynecology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, NetherlandsDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, NetherlandsDepartment of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Rheumatology, Amsterdam Rheumatology and Immunology Center, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Obstetrics and Gynecology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, NetherlandsDepartment of Obstetrics and Gynecology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Obstetrics and Gynecology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, NetherlandsDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, NetherlandsObjective. To investigate disease activity around and during pregnancy and pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first and consecutive pregnancies were examined. Methods. Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists and gynecologists in two tertiary centers in the Netherlands between 2000 and 2015 were included. Disease activity, flare rate, and pregnancy outcomes and complications were assessed. Results. Ninety-six women (84% Caucasian) with 144 pregnancies were included. The median SLE(P)DAI score was 2 before, during, and after pregnancy. Flare rates were 6.3%, 20.1%, and 15.3%, respectively. Severe hypertensive disorder of pregnancy, intrauterine fetal death, preterm birth, and small-for-gestational age infants occurred in 18.1%, 4.1%, 32.7%, and 14.8%, respectively. Complication rates were similar in the first and consecutive pregnancies. Half of the women did not experience any pregnancy complication whereas 42.7% developed a complication during all pregnancies. Mean number of pregnancies was 2.4 and live births 1.7. Conclusion. In this SLE population with low disease activity, pregnancy complications were present irrespective of antiphospholipid antibody status. Furthermore, there were no differences in complication rates between the first and consecutive pregnancies as seen in healthy mothers. This information is useful for patient counseling.http://dx.doi.org/10.1155/2017/8245879 |
| spellingShingle | Sylvia J. Kroese Carolien N. H. Abheiden Birgit S. Blomjous Jacob M. van Laar Ronald W. H. M. Derksen Irene E. M. Bultink Alexandre E. Voskuyl A. Titia Lely Marjon A. de Boer Johanna I. P. de Vries Ruth D. E. Fritsch-Stork Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study Journal of Immunology Research |
| title | Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study |
| title_full | Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study |
| title_fullStr | Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study |
| title_full_unstemmed | Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study |
| title_short | Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study |
| title_sort | maternal and perinatal outcome in women with systemic lupus erythematosus a retrospective bicenter cohort study |
| url | http://dx.doi.org/10.1155/2017/8245879 |
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