Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms

Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms

Abstract The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME). In this study, we constructed nanobubbles loaded with the sonosensitizer HMME and the tumor-targeting...

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Bibliographic Details
Main Authors: Yucao Sun, Yichi Chen, Bolin Wu, Helin Li, Yijun Wang, Xiaodong Wang, Liwen Deng, Kuikun Yang, Xiuhong Wang, Wen Cheng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Cuproptosis
Sonodynamic therapy
Liver hepatocellular carcinoma
Synergistic tumor therapy
RNA sequencing
Online Access:https://doi.org/10.1186/s12951-024-02995-3
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