Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Altho...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Radiology |
| Online Access: | http://dx.doi.org/10.1155/2015/536328 |
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| _version_ | 1849396179594379264 |
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| author | Bruno Araujo Francisco Costa Joanne Lopes Ricardo Castro |
| author_facet | Bruno Araujo Francisco Costa Joanne Lopes Ricardo Castro |
| author_sort | Bruno Araujo |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment. |
| format | Article |
| id | doaj-art-b27a7d7b83d340cc926fa932bec8a35d |
| institution | Kabale University |
| issn | 2090-6862 2090-6870 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Radiology |
| spelling | doaj-art-b27a7d7b83d340cc926fa932bec8a35d2025-08-20T03:39:25ZengWileyCase Reports in Radiology2090-68622090-68702015-01-01201510.1155/2015/536328536328Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary InvolvementBruno Araujo0Francisco Costa1Joanne Lopes2Ricardo Castro3Radiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, PortugalRadiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, PortugalPathology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, PortugalRadiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, PortugalLangerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.http://dx.doi.org/10.1155/2015/536328 |
| spellingShingle | Bruno Araujo Francisco Costa Joanne Lopes Ricardo Castro Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement Case Reports in Radiology |
| title | Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement |
| title_full | Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement |
| title_fullStr | Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement |
| title_full_unstemmed | Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement |
| title_short | Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement |
| title_sort | adult langerhans cell histiocytosis with hepatic and pulmonary involvement |
| url | http://dx.doi.org/10.1155/2015/536328 |
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