Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity

Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity

Conclusions: WES found potentially deleterious rare variants in MODY genes in 8.1% of EOT1D, occurring in the context of a T1D genetic background. Such genetic variants may contribute to disease precipitation by a β-cell dysfunction mechanism. This supports the concept of different endotypes of T1D,...

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Main Authors:	Andreia Fiúza Ribeiro, Ana Laura Fitas, Marcela Oliveira Pires, Paula Matoso, Dário Ligeiro, Daniel Sobral, Carlos Penha-Gonçalves, Jocelyne Demengeot, Íris Caramalho, Catarina Limbert
Format:	Article
Language:	English
Published:	Wiley 2024-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2024/3076895
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