Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

Upon recognizing bacterial lipopolysaccharide (LPS), human TLR4 initiates two distinct signaling pathways: the MyD88 pathway from the cell surface or the TRIF pathway following endocytosis. While the first is associated with strong pro-inflammatory responses, the latter is linked to dendritic cell m...

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Bibliographic Details
Main Authors: Kiruthika Manivannan, Yasmine Fathy Mohamed, Rachel C. Fernandez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Microbiology
Subjects:
Bordetella
LPS
TLR4
MyD88
NFκB
TRIF
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540534/full
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