Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study
Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Th...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/746874 |
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| author | Marinka Mravak-Stipetić Božana Lončar-Brzak Iva Bakale-Hodak Ivan Sabol Sven Seiwerth Martina Majstorović Magdalena Grce |
| author_facet | Marinka Mravak-Stipetić Božana Lončar-Brzak Iva Bakale-Hodak Ivan Sabol Sven Seiwerth Martina Majstorović Magdalena Grce |
| author_sort | Marinka Mravak-Stipetić |
| collection | DOAJ |
| description | Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features. |
| format | Article |
| id | doaj-art-b2763b629cb84fe09219976a5c7f18a1 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b2763b629cb84fe09219976a5c7f18a12025-02-03T01:02:17ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/746874746874Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary StudyMarinka Mravak-Stipetić0Božana Lončar-Brzak1Iva Bakale-Hodak2Ivan Sabol3Sven Seiwerth4Martina Majstorović5Magdalena Grce6Department of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, Department of Oral Medicine, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, CroatiaDepartment of Pediatric Dentistry, School of Dental Medicine, University of Zagreb, 10000 Zagreb, CroatiaSchool of Medicine, Institute of Pathology, University of Zagreb, 10000 Zagreb, CroatiaDivision of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, CroatiaOral lichen planus (OLP) and oral lichenoid lesions (OLL) are clinically and histologically similar lesions but their treatment planning and prognosis are different. The review of the literature indicates numerous criteria to distinguish these two lesions; however there is a lot of inconsistency. Thus, the aim of this study was to determine the correlation of histopathology and clinical OLP and OLL diagnosis and to clarify which histopathologic criteria could best distinguish these two diagnoses. A retrospective study showed that clinically diagnosed 92 OLPs and 14 OLLs have been confirmed histopathologically in 52.2% and 42.9% of cases, respectively. In addition, histopathology showed statistically significant more eosinophils (P<0.0005), plasma cells (P<0.0005), and granulocytes (P<0.05) in OLL than OLP. To establish histopathological diagnosis of OLP and OLL it should be mandatory to define the type of cells in mononuclear infiltrate, which can be associated more accurately with clinical feature and patient history. Therefore, currently accepted diagnostic criteria for OLP and OLL should be modified and validated on a larger number of patients taking into account particular distinguishing histopathological features.http://dx.doi.org/10.1155/2014/746874 |
| spellingShingle | Marinka Mravak-Stipetić Božana Lončar-Brzak Iva Bakale-Hodak Ivan Sabol Sven Seiwerth Martina Majstorović Magdalena Grce Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study The Scientific World Journal |
| title | Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study |
| title_full | Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study |
| title_fullStr | Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study |
| title_full_unstemmed | Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study |
| title_short | Clinicopathologic Correlation of Oral Lichen Planus and Oral Lichenoid Lesions: A Preliminary Study |
| title_sort | clinicopathologic correlation of oral lichen planus and oral lichenoid lesions a preliminary study |
| url | http://dx.doi.org/10.1155/2014/746874 |
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