Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy
Introduction. Breast cancer is the most frequently diagnosed malignancy in women, and comorbidities like hypertension and obesity diminish their quality of life and negatively affect their response to chemotherapy. Furthermore, inulin supplementation is associated with the reduction of cardiovascula...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2019/5707150 |
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| author | Yizel Becerril-Alarcón Saúl Campos-Gómez Juan J. Valdez-Andrade Karen A. Campos-Gómez Diana Y. Reyes-Barretero Alejandra D. Benítez-Arciniega Roxana Valdés-Ramos Alexandra E. Soto-Piña |
| author_facet | Yizel Becerril-Alarcón Saúl Campos-Gómez Juan J. Valdez-Andrade Karen A. Campos-Gómez Diana Y. Reyes-Barretero Alejandra D. Benítez-Arciniega Roxana Valdés-Ramos Alexandra E. Soto-Piña |
| author_sort | Yizel Becerril-Alarcón |
| collection | DOAJ |
| description | Introduction. Breast cancer is the most frequently diagnosed malignancy in women, and comorbidities like hypertension and obesity diminish their quality of life and negatively affect their response to chemotherapy. Furthermore, inulin supplementation is associated with the reduction of cardiovascular diseases (CVD) risk. Objective. To determine whether inulin supplementation prevents the elevation of blood pressure in women with breast cancer undergoing neoadjuvant therapy with cyclophosphamide and doxorubicin. Methods. This was a randomized, double-blind placebo controlled trial which included women with early-stage breast cancer undergoing neoadjuvant therapy (n=38). Patients were randomly assigned to participate in two different groups to receive either 15 g of inulin or 15 g of placebo (maltodextrin) for 21 days. Body composition and blood pressure were evaluated before and after the supplementation period. Results. Women in the inulin group showed a lower systolic blood pressure (SBP) after the supplementation (-4.21 mmHg, p<0.001). However, SBP increased in the placebo supplemented group. Diastolic blood pressure (DBP) nonsignificantly decreased in the inulin group. Inulin supplementation also increased BMI (p<0.001) but reduced BFP (p=0.288). Furthermore, confounding variables, such as BMI, baseline fasting glucose, age, menopause status, vomiting, constipation, and chronic medication did not have a statistical influence over the inulin effect on SBP. Conclusion. Inulin supplementation reduces SBP and prevents increases in DBP in women with breast cancer. This could be an innovative nutraceutical approach to prevent hypertension present in women with this type of cancer at an early stage and may improve the quality of life of the patients and their prognostic development through chemotherapy. Trial Registration Number. This trial is registered with ACTRN12616001532493. |
| format | Article |
| id | doaj-art-b2759dde2f0947f991e8dfdc94bed3c7 |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-b2759dde2f0947f991e8dfdc94bed3c72025-08-20T03:39:25ZengWileyCardiovascular Therapeutics1755-59141755-59222019-01-01201910.1155/2019/57071505707150Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant ChemotherapyYizel Becerril-Alarcón0Saúl Campos-Gómez1Juan J. Valdez-Andrade2Karen A. Campos-Gómez3Diana Y. Reyes-Barretero4Alejandra D. Benítez-Arciniega5Roxana Valdés-Ramos6Alexandra E. Soto-Piña7Facultad de Medicina, Universidad Autónoma del Estado de México, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, MexicoDepartamento de Oncología Médica, Centro Oncológico Estatal ISSEMYM, MexicoDepartamento de Oncología Médica, Centro Oncológico Estatal ISSEMYM, MexicoDepartamento de Oncología Médica, Centro Oncológico Estatal ISSEMYM, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, MexicoIntroduction. Breast cancer is the most frequently diagnosed malignancy in women, and comorbidities like hypertension and obesity diminish their quality of life and negatively affect their response to chemotherapy. Furthermore, inulin supplementation is associated with the reduction of cardiovascular diseases (CVD) risk. Objective. To determine whether inulin supplementation prevents the elevation of blood pressure in women with breast cancer undergoing neoadjuvant therapy with cyclophosphamide and doxorubicin. Methods. This was a randomized, double-blind placebo controlled trial which included women with early-stage breast cancer undergoing neoadjuvant therapy (n=38). Patients were randomly assigned to participate in two different groups to receive either 15 g of inulin or 15 g of placebo (maltodextrin) for 21 days. Body composition and blood pressure were evaluated before and after the supplementation period. Results. Women in the inulin group showed a lower systolic blood pressure (SBP) after the supplementation (-4.21 mmHg, p<0.001). However, SBP increased in the placebo supplemented group. Diastolic blood pressure (DBP) nonsignificantly decreased in the inulin group. Inulin supplementation also increased BMI (p<0.001) but reduced BFP (p=0.288). Furthermore, confounding variables, such as BMI, baseline fasting glucose, age, menopause status, vomiting, constipation, and chronic medication did not have a statistical influence over the inulin effect on SBP. Conclusion. Inulin supplementation reduces SBP and prevents increases in DBP in women with breast cancer. This could be an innovative nutraceutical approach to prevent hypertension present in women with this type of cancer at an early stage and may improve the quality of life of the patients and their prognostic development through chemotherapy. Trial Registration Number. This trial is registered with ACTRN12616001532493.http://dx.doi.org/10.1155/2019/5707150 |
| spellingShingle | Yizel Becerril-Alarcón Saúl Campos-Gómez Juan J. Valdez-Andrade Karen A. Campos-Gómez Diana Y. Reyes-Barretero Alejandra D. Benítez-Arciniega Roxana Valdés-Ramos Alexandra E. Soto-Piña Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy Cardiovascular Therapeutics |
| title | Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy |
| title_full | Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy |
| title_fullStr | Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy |
| title_full_unstemmed | Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy |
| title_short | Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy |
| title_sort | inulin supplementation reduces systolic blood pressure in women with breast cancer undergoing neoadjuvant chemotherapy |
| url | http://dx.doi.org/10.1155/2019/5707150 |
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