Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection
Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/281425 |
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| _version_ | 1832568454216941568 |
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| author | Shixing Tang Indira K. Hewlett |
| author_facet | Shixing Tang Indira K. Hewlett |
| author_sort | Shixing Tang |
| collection | DOAJ |
| description | Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in 2010, several test methods including nucleic acid testing methods and serological assays have been developed for detection of XMRV and/or MLV-like sequences. However, these research assays have not yet been validated and evaluated due to the lack of well-characterized reference materials. Mouse DNA contamination should be carefully checked when testing human specimens in order to avoid false-positive detection of XMRV or MLV-like sequences. |
| format | Article |
| id | doaj-art-b27397a85d9c4600b89ce66d0c7d0a3f |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-b27397a85d9c4600b89ce66d0c7d0a3f2025-02-03T00:59:00ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/281425281425Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus InfectionShixing Tang0Indira K. Hewlett1Laboratory of Molecular Virology, CBER, Food and Drug Administration, Bethesda, MD 20892, USALaboratory of Molecular Virology, CBER, Food and Drug Administration, Bethesda, MD 20892, USAXenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in 2010, several test methods including nucleic acid testing methods and serological assays have been developed for detection of XMRV and/or MLV-like sequences. However, these research assays have not yet been validated and evaluated due to the lack of well-characterized reference materials. Mouse DNA contamination should be carefully checked when testing human specimens in order to avoid false-positive detection of XMRV or MLV-like sequences.http://dx.doi.org/10.1155/2011/281425 |
| spellingShingle | Shixing Tang Indira K. Hewlett Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection Advances in Virology |
| title | Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_full | Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_fullStr | Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_full_unstemmed | Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_short | Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_sort | testing strategies for detection of xenotropic murine leukemia virus related virus infection |
| url | http://dx.doi.org/10.1155/2011/281425 |
| work_keys_str_mv | AT shixingtang testingstrategiesfordetectionofxenotropicmurineleukemiavirusrelatedvirusinfection AT indirakhewlett testingstrategiesfordetectionofxenotropicmurineleukemiavirusrelatedvirusinfection |