Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives

Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives

Guanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma)...

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Bibliographic Details
Main Authors: França Paulo H. B., Da Silva-Júnior Edeildo F., Aquino Pedro G. V., Santana Antônio E. G., Ferro Jamylle N. S., De Oliveira Barreto Emiliano, Do Ó Pessoa Cláudia, Meira Assuero Silva, De Aquino Thiago M., Alexandre-Moreira Magna S., Schmitt Martine, De Araújo-Júnior João X.
Format: Article
Language:English
Published: Sciendo 2016-03-01
Series:Acta Pharmaceutica
Subjects:
guanylhydrazone
cytotoxic effect
synthesis
mtt assay
Online Access:https://doi.org/10.1515/acph-2016-0015
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