Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness
Arterial stiffness is strongly associated with vascular aging and pathology and can be assessed in many ways. Existing devices for measuring central arterial stiffness, such as carotid-femoral pulse wave velocity (PWV), are limited by high costs and the need for specialized expertise, limiting wides...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1481836/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591052728434688 |
|---|---|
| author | T. Corina Margain Emily Powell Alexandra Clark Adam Bush |
| author_facet | T. Corina Margain Emily Powell Alexandra Clark Adam Bush |
| author_sort | T. Corina Margain |
| collection | DOAJ |
| description | Arterial stiffness is strongly associated with vascular aging and pathology and can be assessed in many ways. Existing devices for measuring central arterial stiffness, such as carotid-femoral pulse wave velocity (PWV), are limited by high costs and the need for specialized expertise, limiting widespread clinical adoption. This study introduces a semi- and non-occlusive PWV measurement system using phonocardiography (PCG) and plethysmography (PPG) and a single femoral pressure cuff, aiming to address these limitations. We conducted a study comparing a semi-occlusive (carotid-femoral PWV) and a non-occlusive (carotid-toe PWV) PCG-based PWV measurements across a cohort of 63 volunteers, as compared to literature reference PWV values. Results demonstrated strong correlations between our PCG-based PWV measures (PWVcarotid−femoral: 8.42 ± 3.99 m/s vs. PWVcarotid−toe: 10.62 ± 3.86 m/s) with age as a significant predictor (PWVcarotid−femoral: r2 = 0.45; PWVcarotid−toe: r2 = 0.28, p < 0.05). Ultrasound measured distensibility assessments confirmed the reliability of our PCG approach in reflecting central arterial stiffness dynamics, particularly at the aortic level. Test–retest reliability analyses yielded high intraclass correlation coefficients (0.75 ≤ ICC ≤ 90), indicating robust repeatability of our method. This study highlights the feasibility and accuracy of our low-cost, semi and non-occlusive PWV measurement systems to enhance accessibility in arterial stiffness assessments, potentially easing cardiovascular risk stratification. |
| format | Article |
| id | doaj-art-b260abb1516b41b79aed70d09bf54da8 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b260abb1516b41b79aed70d09bf54da82025-01-23T05:10:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.14818361481836Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffnessT. Corina Margain0Emily Powell1Alexandra Clark2Adam Bush3Biomedical Engineering Department, Translational Cardiovascular Imaging Group, The University of Texas at Austin, Austin, TX, United StatesBiomedical Engineering Department, Translational Cardiovascular Imaging Group, The University of Texas at Austin, Austin, TX, United StatesMechanisms Underlying Neurocognitive Aging Laboratory, Department of Psychology, The University of Texas at Austin, Austin, TX, United StatesBiomedical Engineering Department, Translational Cardiovascular Imaging Group, The University of Texas at Austin, Austin, TX, United StatesArterial stiffness is strongly associated with vascular aging and pathology and can be assessed in many ways. Existing devices for measuring central arterial stiffness, such as carotid-femoral pulse wave velocity (PWV), are limited by high costs and the need for specialized expertise, limiting widespread clinical adoption. This study introduces a semi- and non-occlusive PWV measurement system using phonocardiography (PCG) and plethysmography (PPG) and a single femoral pressure cuff, aiming to address these limitations. We conducted a study comparing a semi-occlusive (carotid-femoral PWV) and a non-occlusive (carotid-toe PWV) PCG-based PWV measurements across a cohort of 63 volunteers, as compared to literature reference PWV values. Results demonstrated strong correlations between our PCG-based PWV measures (PWVcarotid−femoral: 8.42 ± 3.99 m/s vs. PWVcarotid−toe: 10.62 ± 3.86 m/s) with age as a significant predictor (PWVcarotid−femoral: r2 = 0.45; PWVcarotid−toe: r2 = 0.28, p < 0.05). Ultrasound measured distensibility assessments confirmed the reliability of our PCG approach in reflecting central arterial stiffness dynamics, particularly at the aortic level. Test–retest reliability analyses yielded high intraclass correlation coefficients (0.75 ≤ ICC ≤ 90), indicating robust repeatability of our method. This study highlights the feasibility and accuracy of our low-cost, semi and non-occlusive PWV measurement systems to enhance accessibility in arterial stiffness assessments, potentially easing cardiovascular risk stratification.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1481836/fullarterial stiffnesspulse wave velocityphonocardiographyplethysmographycardiovascular health |
| spellingShingle | T. Corina Margain Emily Powell Alexandra Clark Adam Bush Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness Frontiers in Cardiovascular Medicine arterial stiffness pulse wave velocity phonocardiography plethysmography cardiovascular health |
| title | Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness |
| title_full | Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness |
| title_fullStr | Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness |
| title_full_unstemmed | Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness |
| title_short | Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness |
| title_sort | phonocardiography based pulse wave velocity system for non occlusive assessment of arterial stiffness |
| topic | arterial stiffness pulse wave velocity phonocardiography plethysmography cardiovascular health |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1481836/full |
| work_keys_str_mv | AT tcorinamargain phonocardiographybasedpulsewavevelocitysystemfornonocclusiveassessmentofarterialstiffness AT emilypowell phonocardiographybasedpulsewavevelocitysystemfornonocclusiveassessmentofarterialstiffness AT alexandraclark phonocardiographybasedpulsewavevelocitysystemfornonocclusiveassessmentofarterialstiffness AT adambush phonocardiographybasedpulsewavevelocitysystemfornonocclusiveassessmentofarterialstiffness |