Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae
Background and Aim: Streptococcosis, caused by Streptococcus agalactiae, is a significant disease in tilapia farming that results in substantial economic losses. While vaccination is the most effective method for prevention, current vaccines face challenges when administered orally or through immers...
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Veterinary World
2025-07-01
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| Series: | Veterinary World |
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| Online Access: | https://www.veterinaryworld.org/Vol.18/July-2025/2.pdf |
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| author | Angela Mariana Lusiastuti Siti Nurul Aisyiyah Jenie Melati Septiyanti Yulianti Sampora Tanjung Penataseputro Thavasimutu Citarasu Desy Sugiani Dewi Syahidah Indah Dwiatmi Dewijanti Hessy Novita Tuti Sumiati Uni Purwaningsih Suryanto Suryanto Brata Pantjara Taufik Hadi Ramli Pramuanggit Panggih Nugroho Khairun Nisaa Annisa Wening Maharani Putri |
| author_facet | Angela Mariana Lusiastuti Siti Nurul Aisyiyah Jenie Melati Septiyanti Yulianti Sampora Tanjung Penataseputro Thavasimutu Citarasu Desy Sugiani Dewi Syahidah Indah Dwiatmi Dewijanti Hessy Novita Tuti Sumiati Uni Purwaningsih Suryanto Suryanto Brata Pantjara Taufik Hadi Ramli Pramuanggit Panggih Nugroho Khairun Nisaa Annisa Wening Maharani Putri |
| author_sort | Angela Mariana Lusiastuti |
| collection | DOAJ |
| description | Background and Aim: Streptococcosis, caused by Streptococcus agalactiae, is a significant disease in tilapia farming that results in substantial economic losses. While vaccination is the most effective method for prevention, current vaccines face challenges when administered orally or through immersion, primarily due to poor absorption and degradation in the fish’s digestive system. Nanotechnology offers new ways to improve vaccine delivery and effectiveness. This review compares two nanoparticle (NPs)-based systems – nanoemulsions and silica NPs (SiNP) – for delivering vaccines to tilapia. Nanoemulsions are small, stable droplets that protect the vaccine and help it stick to mucosal surfaces, making them more effective in triggering immune responses. SiNP are highly stable and can protect vaccines under harsh conditions but still face challenges in particle size and vaccine loading. The review highlights important factors, including particle size, stability, and surfactant composition, that affect the vaccine’s effectiveness. In practical terms, nanoemulsions are more suitable for use in Indonesia’s tropical aquaculture settings because they are easier to apply, more stable, and more effective in their current formulations. Further research is needed to improve both systems, especially to ensure long-term safety, improve delivery to mucosal tissues, and reduce production costs. Nanotechnology-based vaccines have a strong potential to improve fish health and reduce antibiotic use in aquaculture. |
| format | Article |
| id | doaj-art-b259e33ea94b4973b54542f1b6cee6fb |
| institution | Kabale University |
| issn | 0972-8988 2231-0916 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj-art-b259e33ea94b4973b54542f1b6cee6fb2025-08-20T03:28:10ZengVeterinary WorldVeterinary World0972-89882231-09162025-07-011871807181810.14202/vetworld.2025.1807-1818Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiaeAngela Mariana Lusiastuti0https://orcid.org/0000-0003-2980-4224Siti Nurul Aisyiyah Jenie1https://orcid.org/0000-0001-9387-023XMelati Septiyanti2https://orcid.org/0000-0002-7512-9795Yulianti Sampora3https://orcid.org/0000-0002-8197-4258Tanjung Penataseputro4https://orcid.org/0000-0002-9645-0713Thavasimutu Citarasu5https://orcid.org/0000-0001-6166-620XDesy Sugiani6https://orcid.org/0000-0001-5223-3568Dewi Syahidah7https://orcid.org/0000-0002-4902-0518Indah Dwiatmi Dewijanti8https://orcid.org/0000-0003-4650-7192Hessy Novita9https://orcid.org/0000-0003-1394-6666Tuti Sumiati10https://orcid.org/0000-0003-3365-9576Uni Purwaningsih11https://orcid.org/0009-0009-3583-0585Suryanto Suryanto12https://orcid.org/0000-0001-5073-6452Brata Pantjara13https://orcid.org/0009-0000-2790-629XTaufik Hadi Ramli14https://orcid.org/0009-0004-3459-369XPramuanggit Panggih Nugroho15https://orcid.org/0009-0002-5859-4123Khairun Nisaa16https://orcid.org/0000-0001-7672-4548Annisa Wening Maharani Putri17https://orcid.org/0000-0002-4054-6097Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Advanced Chemistry, National Research and Innovation Agency, Jl. Raya Puspiptek 60, Setu, Tangerang Selatan, 15314, Banten, Indonesia.Research Center for Advanced Chemistry, National Research and Innovation Agency, Jl. Raya Puspiptek 60, Setu, Tangerang Selatan, 15314, Banten, Indonesia.Research Center for Advanced Chemistry, National Research and Innovation Agency, Jl. Raya Puspiptek 60, Setu, Tangerang Selatan, 15314, Banten, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Marina Campus, Rajakkamangalam, Kanyakumari District, Tamil Nadu, 629502, India.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Fisheries, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Fisheries, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Department of Aquaculture, The Marine and Fisheries Polytechnic Karawang, The Ministry of Marine Affairs and Fisheries, Jl. Raya Lingkar Tanjungpura-Klari, Karang Pawitan, Karawang Barat, Karawang, 41314, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Research Center for Veterinary Science, National Research and Innovation Agency, Jl. Raya Bogor Km. 46 Cibinong, Bogor, 16911, West Java, Indonesia.Background and Aim: Streptococcosis, caused by Streptococcus agalactiae, is a significant disease in tilapia farming that results in substantial economic losses. While vaccination is the most effective method for prevention, current vaccines face challenges when administered orally or through immersion, primarily due to poor absorption and degradation in the fish’s digestive system. Nanotechnology offers new ways to improve vaccine delivery and effectiveness. This review compares two nanoparticle (NPs)-based systems – nanoemulsions and silica NPs (SiNP) – for delivering vaccines to tilapia. Nanoemulsions are small, stable droplets that protect the vaccine and help it stick to mucosal surfaces, making them more effective in triggering immune responses. SiNP are highly stable and can protect vaccines under harsh conditions but still face challenges in particle size and vaccine loading. The review highlights important factors, including particle size, stability, and surfactant composition, that affect the vaccine’s effectiveness. In practical terms, nanoemulsions are more suitable for use in Indonesia’s tropical aquaculture settings because they are easier to apply, more stable, and more effective in their current formulations. Further research is needed to improve both systems, especially to ensure long-term safety, improve delivery to mucosal tissues, and reduce production costs. Nanotechnology-based vaccines have a strong potential to improve fish health and reduce antibiotic use in aquaculture.https://www.veterinaryworld.org/Vol.18/July-2025/2.pdffish healthmucosal vaccinenanoemulsionnanovaccinesilica nanoparticlesstreptococcus agalactiaetilapia |
| spellingShingle | Angela Mariana Lusiastuti Siti Nurul Aisyiyah Jenie Melati Septiyanti Yulianti Sampora Tanjung Penataseputro Thavasimutu Citarasu Desy Sugiani Dewi Syahidah Indah Dwiatmi Dewijanti Hessy Novita Tuti Sumiati Uni Purwaningsih Suryanto Suryanto Brata Pantjara Taufik Hadi Ramli Pramuanggit Panggih Nugroho Khairun Nisaa Annisa Wening Maharani Putri Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae Veterinary World fish health mucosal vaccine nanoemulsion nanovaccine silica nanoparticles streptococcus agalactiae tilapia |
| title | Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae |
| title_full | Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae |
| title_fullStr | Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae |
| title_full_unstemmed | Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae |
| title_short | Nanotechnology-driven strategies for tilapia vaccines: Comparative evaluation of nanoemulsions and silica nanoparticles against Streptococcus agalactiae |
| title_sort | nanotechnology driven strategies for tilapia vaccines comparative evaluation of nanoemulsions and silica nanoparticles against streptococcus agalactiae |
| topic | fish health mucosal vaccine nanoemulsion nanovaccine silica nanoparticles streptococcus agalactiae tilapia |
| url | https://www.veterinaryworld.org/Vol.18/July-2025/2.pdf |
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