The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
Abstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 ye...
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2025-01-01
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Online Access: | https://doi.org/10.1186/s13063-025-08740-x |
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author | Kasra Saeedian Saeed Davaryar Maryam Emadzadeh Alireza Akhavan Rezayat |
author_facet | Kasra Saeedian Saeed Davaryar Maryam Emadzadeh Alireza Akhavan Rezayat |
author_sort | Kasra Saeedian |
collection | DOAJ |
description | Abstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05. Results A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001). Conclusion Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements. Trial registration This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020. |
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institution | Kabale University |
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language | English |
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spelling | doaj-art-b259cd778573448ca20037c53dc0dbf32025-02-02T12:41:33ZengBMCTrials1745-62152025-01-012611510.1186/s13063-025-08740-xThe impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trialKasra Saeedian0Saeed Davaryar1Maryam Emadzadeh2Alireza Akhavan Rezayat3Department of Radiology, Babol University of Medical SciencesFaculty of Medicine, Mashhad University of Medical SciencesClinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical SciencesDepartment of Urology, Ghaem Hospital, Mashhad University of Medical ScienceAbstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05. Results A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001). Conclusion Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements. Trial registration This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.https://doi.org/10.1186/s13063-025-08740-xVaricocelectomyVitamin EInfertilitySperm analysis |
spellingShingle | Kasra Saeedian Saeed Davaryar Maryam Emadzadeh Alireza Akhavan Rezayat The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial Trials Varicocelectomy Vitamin E Infertility Sperm analysis |
title | The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial |
title_full | The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial |
title_fullStr | The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial |
title_full_unstemmed | The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial |
title_short | The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial |
title_sort | impact of vitamin e supplementation on sperm analysis in varicocelectomy patients a triple blind randomized controlled trial |
topic | Varicocelectomy Vitamin E Infertility Sperm analysis |
url | https://doi.org/10.1186/s13063-025-08740-x |
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