The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial

Abstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 ye...

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Main Authors: Kasra Saeedian, Saeed Davaryar, Maryam Emadzadeh, Alireza Akhavan Rezayat
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Trials
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Online Access:https://doi.org/10.1186/s13063-025-08740-x
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author Kasra Saeedian
Saeed Davaryar
Maryam Emadzadeh
Alireza Akhavan Rezayat
author_facet Kasra Saeedian
Saeed Davaryar
Maryam Emadzadeh
Alireza Akhavan Rezayat
author_sort Kasra Saeedian
collection DOAJ
description Abstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05. Results A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001). Conclusion Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements. Trial registration This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.
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spelling doaj-art-b259cd778573448ca20037c53dc0dbf32025-02-02T12:41:33ZengBMCTrials1745-62152025-01-012611510.1186/s13063-025-08740-xThe impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trialKasra Saeedian0Saeed Davaryar1Maryam Emadzadeh2Alireza Akhavan Rezayat3Department of Radiology, Babol University of Medical SciencesFaculty of Medicine, Mashhad University of Medical SciencesClinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical SciencesDepartment of Urology, Ghaem Hospital, Mashhad University of Medical ScienceAbstract Objective To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy. Martials and method This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15–25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05. Results A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001). Conclusion Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements. Trial registration This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.https://doi.org/10.1186/s13063-025-08740-xVaricocelectomyVitamin EInfertilitySperm analysis
spellingShingle Kasra Saeedian
Saeed Davaryar
Maryam Emadzadeh
Alireza Akhavan Rezayat
The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
Trials
Varicocelectomy
Vitamin E
Infertility
Sperm analysis
title The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
title_full The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
title_fullStr The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
title_full_unstemmed The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
title_short The impact of vitamin E supplementation on sperm analysis in varicocelectomy patients: a triple-blind randomized controlled trial
title_sort impact of vitamin e supplementation on sperm analysis in varicocelectomy patients a triple blind randomized controlled trial
topic Varicocelectomy
Vitamin E
Infertility
Sperm analysis
url https://doi.org/10.1186/s13063-025-08740-x
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