The role of the glutathione pathway in tracheal regeneration with aortic allografts through antioxidant-driven tissue integration
Abstract Tracheal regeneration remains a major challenge due to the lack of efficient graft integration and functional restoration. Current approaches fail to address oxidative stress-induced tissue remodeling. Here, we show that the glutathione pathway plays a pivotal role in tracheal regeneration...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07741-5 |
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| Summary: | Abstract Tracheal regeneration remains a major challenge due to the lack of efficient graft integration and functional restoration. Current approaches fail to address oxidative stress-induced tissue remodeling. Here, we show that the glutathione pathway plays a pivotal role in tracheal regeneration with aortic allografts by modulating redox homeostasis and promoting host-graft integration. Through transcriptomic profiling, histological analyses, and functional assessment, we demonstrate that antioxidant-driven tissue remodeling enhances epithelialization, neovascularization, and extracellular matrix organization, thereby improving graft stability and biomechanical properties. These findings provide mechanistic insights into oxidative stress-mediated tissue remodeling and suggest that targeting redox signaling could optimize bioengineered tracheal grafts for clinical translation. |
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| ISSN: | 2399-3642 |