Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a systemic disease that is associated with increased serum levels of markers of systemic inflammation. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently identified activating receptor on neutrophils,...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2007/52040 |
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| author | Markus P. Radsak Christian Taube Philipp Haselmayer Stefan Tenzer Helmut R. Salih Rainer Wiewrodt Roland Buhl Hansjörg Schild |
| author_facet | Markus P. Radsak Christian Taube Philipp Haselmayer Stefan Tenzer Helmut R. Salih Rainer Wiewrodt Roland Buhl Hansjörg Schild |
| author_sort | Markus P. Radsak |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a systemic disease that is associated with increased serum levels of markers of systemic inflammation. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently identified activating receptor on neutrophils, monocytes, and macrophage subsets. TREM-1 expression is upregulated by microbial products such as the toll-like receptor ligand lipoteichoic acid of Gram-positive or lipopolysaccharides of Gram-negative bacteria. In the present study, sera from 12 COPD patients (GOLD stages I–IV, FEV1 51 ± 6%) and 10 healthy individuals were retrospectively analyzed for soluble TREM-1 (sTREM-1) using a newly developed ELISA. In healthy subjects, sTREM-1 levels were low (median 0.25 ng/mL, range 0–5.9 ng/mL). In contrast, levels of sTREM-1 in sera of COPD patients were significantly increased (median 11.68 ng/mL, range 6.2–41.9 ng/mL, P<.05). Furthermore, serum levels of sTREM-1 showed a significant negative correlation with lung function impairment. In summary, serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD. |
| format | Article |
| id | doaj-art-b24de1a54cdb4cc09b39f9f712477c64 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b24de1a54cdb4cc09b39f9f712477c642025-08-20T03:39:26ZengWileyClinical and Developmental Immunology1740-25221740-25302007-01-01200710.1155/2007/5204052040Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary DiseaseMarkus P. Radsak0Christian Taube1Philipp Haselmayer2Stefan Tenzer3Helmut R. Salih4Rainer Wiewrodt5Roland Buhl6Hansjörg Schild7Institute of Immunology, University of Mainz, Obere Zahlbacher Street 67, Mainz 55131, GermanyIII Medical Clinic, University of Mainz, Langenbeck Street 1, Mainz 55101, GermanyInstitute of Immunology, University of Mainz, Obere Zahlbacher Street 67, Mainz 55131, GermanyInstitute of Immunology, University of Mainz, Obere Zahlbacher Street 67, Mainz 55131, GermanyUniversity Medical Hospital, Department of Medicine II, University of Tübingen, Otfried-Müller-Street 10, Tübingen 72076, GermanyIII Medical Clinic, University of Mainz, Langenbeck Street 1, Mainz 55101, GermanyIII Medical Clinic, University of Mainz, Langenbeck Street 1, Mainz 55101, GermanyInstitute of Immunology, University of Mainz, Obere Zahlbacher Street 67, Mainz 55131, GermanyChronic obstructive pulmonary disease (COPD) is increasingly recognized as a systemic disease that is associated with increased serum levels of markers of systemic inflammation. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently identified activating receptor on neutrophils, monocytes, and macrophage subsets. TREM-1 expression is upregulated by microbial products such as the toll-like receptor ligand lipoteichoic acid of Gram-positive or lipopolysaccharides of Gram-negative bacteria. In the present study, sera from 12 COPD patients (GOLD stages I–IV, FEV1 51 ± 6%) and 10 healthy individuals were retrospectively analyzed for soluble TREM-1 (sTREM-1) using a newly developed ELISA. In healthy subjects, sTREM-1 levels were low (median 0.25 ng/mL, range 0–5.9 ng/mL). In contrast, levels of sTREM-1 in sera of COPD patients were significantly increased (median 11.68 ng/mL, range 6.2–41.9 ng/mL, P<.05). Furthermore, serum levels of sTREM-1 showed a significant negative correlation with lung function impairment. In summary, serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD.http://dx.doi.org/10.1155/2007/52040 |
| spellingShingle | Markus P. Radsak Christian Taube Philipp Haselmayer Stefan Tenzer Helmut R. Salih Rainer Wiewrodt Roland Buhl Hansjörg Schild Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease Clinical and Developmental Immunology |
| title | Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full | Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_fullStr | Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_short | Soluble Triggering Receptor Expressed on Myeloid Cells 1 Is Released in Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_sort | soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2007/52040 |
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