Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study
Background. Intra-articular bone marrow concentrate (BMC) and aspirate (BMA) injections have been used with mixed results to treat osteoarthritis (OA). Given the various aspiration and concentration methods available for preparing bone marrow, more data are needed to identify the optimal bone marrow...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/5394441 |
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| author | Daniel Kuebler Alexandra Schnee Lisa Moore Jason Kouri Alexis McLaughlin Robert Hanson Patrick Kuebler Ignacio Dallo Alberto Gobbi |
| author_facet | Daniel Kuebler Alexandra Schnee Lisa Moore Jason Kouri Alexis McLaughlin Robert Hanson Patrick Kuebler Ignacio Dallo Alberto Gobbi |
| author_sort | Daniel Kuebler |
| collection | DOAJ |
| description | Background. Intra-articular bone marrow concentrate (BMC) and aspirate (BMA) injections have been used with mixed results to treat osteoarthritis (OA). Given the various aspiration and concentration methods available for preparing bone marrow, more data are needed to identify the optimal bone marrow harvesting techniques to treat OA. Methods. This retrospective cohort study examined the effect of using low-volume BMAs harvested using the Marrow Cellution™ (MC) device on 160 patients (262 knees) suffering from pain due to knee OA, KL grades 2-4, that did not respond to conservative treatment. Changes in visual analog scores (VAS) for overall daily activity were examined over a six-month time frame in these patients (63.5±0.97 years of age; 48.1% male). In addition, changes in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Patient Global Impression of Change (PGIC scores) were examined over the same time frame in a smaller subset of patients (95 patients including 172 knees). Results. There was a statistically significant improvement in VAS scores for overall daily activity 6 months postprocedure in the study population, 7.29±0.27 vs. 3.76±0.34 (p<0.0001), as well as statistically significant improvements in WOMAC scores, 49.3±4.27 vs. 66.3±4.08 (p<0.0001). On the individual level, 71% of the cases displayed VAS improvements and 61% of the cases displayed WOMAC improvements that exceeded levels previous studies determined to be the minimal clinically important difference (MCID) for knee OA treatments. The improvements in WOMAC scores were also seen in both the WOMAC pain subscore, 52.2±4.39 vs. 72.2±4.36 (p<0.0001) and the WOMAC function subscore, 51.6±4.67 vs. 69.0±4.36 (p<0.0001). In addition, the PGIC scores measuring patient satisfaction improved from 4.03±0.26 at 6 weeks postprocedure to 4.65±0.28 at 6 months postprocedure (p<0.0001). Conclusions. Knee OA patients treated with MC BMA intra-articular injections exhibited significant reductions in VAS pain scores and significant improvements in WOMAC scores that exceeded the minimal clinically important difference thresholds. In addition, reductions in VAS pain scores and improvements in WOMAC scores correlated with higher PGIC scores. |
| format | Article |
| id | doaj-art-b243e644a57f43fda8cb597d61b4fd0a |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b243e644a57f43fda8cb597d61b4fd0a2025-02-03T05:57:54ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/5394441Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort StudyDaniel Kuebler0Alexandra Schnee1Lisa Moore2Jason Kouri3Alexis McLaughlin4Robert Hanson5Patrick Kuebler6Ignacio Dallo7Alberto Gobbi8Department of BiologyAtlas Medical CenterAtlas Medical CenterAtlas Medical CenterAtlas Medical CenterAtlas Medical CenterDepartment of BiologyO.A.S.I. Bioresearch FoundationO.A.S.I. Bioresearch FoundationBackground. Intra-articular bone marrow concentrate (BMC) and aspirate (BMA) injections have been used with mixed results to treat osteoarthritis (OA). Given the various aspiration and concentration methods available for preparing bone marrow, more data are needed to identify the optimal bone marrow harvesting techniques to treat OA. Methods. This retrospective cohort study examined the effect of using low-volume BMAs harvested using the Marrow Cellution™ (MC) device on 160 patients (262 knees) suffering from pain due to knee OA, KL grades 2-4, that did not respond to conservative treatment. Changes in visual analog scores (VAS) for overall daily activity were examined over a six-month time frame in these patients (63.5±0.97 years of age; 48.1% male). In addition, changes in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Patient Global Impression of Change (PGIC scores) were examined over the same time frame in a smaller subset of patients (95 patients including 172 knees). Results. There was a statistically significant improvement in VAS scores for overall daily activity 6 months postprocedure in the study population, 7.29±0.27 vs. 3.76±0.34 (p<0.0001), as well as statistically significant improvements in WOMAC scores, 49.3±4.27 vs. 66.3±4.08 (p<0.0001). On the individual level, 71% of the cases displayed VAS improvements and 61% of the cases displayed WOMAC improvements that exceeded levels previous studies determined to be the minimal clinically important difference (MCID) for knee OA treatments. The improvements in WOMAC scores were also seen in both the WOMAC pain subscore, 52.2±4.39 vs. 72.2±4.36 (p<0.0001) and the WOMAC function subscore, 51.6±4.67 vs. 69.0±4.36 (p<0.0001). In addition, the PGIC scores measuring patient satisfaction improved from 4.03±0.26 at 6 weeks postprocedure to 4.65±0.28 at 6 months postprocedure (p<0.0001). Conclusions. Knee OA patients treated with MC BMA intra-articular injections exhibited significant reductions in VAS pain scores and significant improvements in WOMAC scores that exceeded the minimal clinically important difference thresholds. In addition, reductions in VAS pain scores and improvements in WOMAC scores correlated with higher PGIC scores.http://dx.doi.org/10.1155/2022/5394441 |
| spellingShingle | Daniel Kuebler Alexandra Schnee Lisa Moore Jason Kouri Alexis McLaughlin Robert Hanson Patrick Kuebler Ignacio Dallo Alberto Gobbi Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study Stem Cells International |
| title | Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study |
| title_full | Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study |
| title_fullStr | Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study |
| title_full_unstemmed | Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study |
| title_short | Short-Term Efficacy of Using a Novel Low-Volume Bone Marrow Aspiration Technique to Treat Knee Osteoarthritis: A Retrospective Cohort Study |
| title_sort | short term efficacy of using a novel low volume bone marrow aspiration technique to treat knee osteoarthritis a retrospective cohort study |
| url | http://dx.doi.org/10.1155/2022/5394441 |
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