Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice

Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice

Summary: Latent viral reservoirs (VRs) represent a main barrier to HIV cure. Thus, developing new approaches that can purge and eliminate VRs paves the path toward achieving an HIV-1 cure. APG-1387, a bivalent SMAC mimetic (SM), efficiently reactivates latent HIV expression in T cell line models and...

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Bibliographic Details
Main Authors: Jaspreet Jain, Tram N.Q. Pham, Sharmin Begum, Maria Carmen Romero-Medina, Nicolas Bellini, Yuanyi Li, Frédéric Dallaire, Kathie Béland, Natasha Patey, Jean V. Guimond, Élie Haddad, Yifan Zhai, Éric A. Cohen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Immunology
Virology
Natural sciences
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422402697X
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