Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients
Abstract Objective: To characterize a cohort of pediatric thyroid cancer patients, focusing on clinical features and outcomes stratified by age. Subjects and methods: This retrospective analysis included 63 pediatric differentiated thyroid cancer patients treated at a Portuguese pediatric referenc...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2025-04-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201102&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849722060393152512 |
|---|---|
| author | Laura Leite-Almeida Rita Santos Silva Margarida Vicente-Ferreira Carla Costa Norberto Estevinho Cíntia Castro-Correia Sofia Ferreira Maria Bom-Sucesso |
| author_facet | Laura Leite-Almeida Rita Santos Silva Margarida Vicente-Ferreira Carla Costa Norberto Estevinho Cíntia Castro-Correia Sofia Ferreira Maria Bom-Sucesso |
| author_sort | Laura Leite-Almeida |
| collection | DOAJ |
| description | Abstract Objective: To characterize a cohort of pediatric thyroid cancer patients, focusing on clinical features and outcomes stratified by age. Subjects and methods: This retrospective analysis included 63 pediatric differentiated thyroid cancer patients treated at a Portuguese pediatric reference hospital over a period of 20 years. Data extracted from clinical records covered demographics, clinical presentation, family history, tumor characteristics, treatment modalities, complications, disease status, and survival outcomes. Patients younger than 12 years were compared to those aged 12 and older. Results: The mean age at diagnosis of the sample was 14.5 years, with a preponderance of female patients. Clinical presentation varied significantly between age groups; younger patients were more likely to present palpable cervical lymph nodes, while older patients frequently had solitary thyroid nodules. Family history and identifiable risk factors were similar across groups. However, older patients had higher rates of prior neoplasia and radiation exposure. Age also influenced surgical treatment and outcomes, including complications and recurrence rates. Conclusion: Our findings corroborate previous evidence on the predominance of papillary carcinoma and the association between radiation exposure and thyroid cancer. Younger patients demonstrated more aggressive tumor characteristics and higher recurrence rates, underscoring the need for age-specific management strategies. Early detection, comprehensive surgical intervention, and multidisciplinary follow-up are essential for achieving optimal outcomes. |
| format | Article |
| id | doaj-art-b23ef7d30fc84efd821bbf89d6cd0c7e |
| institution | DOAJ |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-b23ef7d30fc84efd821bbf89d6cd0c7e2025-08-20T03:11:28ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-04-0169210.20945/2359-4292-2024-0333Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patientsLaura Leite-Almeidahttps://orcid.org/0000-0003-2319-1332Rita Santos Silvahttps://orcid.org/0000-0002-0338-3399Margarida Vicente-Ferreirahttps://orcid.org/0000-0002-8385-5041Carla Costahttps://orcid.org/0000-0003-4294-9604Norberto Estevinhohttps://orcid.org/0009-0001-2607-3465Cíntia Castro-Correiahttps://orcid.org/0000-0002-5967-0231Sofia Ferreirahttps://orcid.org/0000-0001-7947-0598Maria Bom-Sucessohttps://orcid.org/0000-0003-4611-3329Abstract Objective: To characterize a cohort of pediatric thyroid cancer patients, focusing on clinical features and outcomes stratified by age. Subjects and methods: This retrospective analysis included 63 pediatric differentiated thyroid cancer patients treated at a Portuguese pediatric reference hospital over a period of 20 years. Data extracted from clinical records covered demographics, clinical presentation, family history, tumor characteristics, treatment modalities, complications, disease status, and survival outcomes. Patients younger than 12 years were compared to those aged 12 and older. Results: The mean age at diagnosis of the sample was 14.5 years, with a preponderance of female patients. Clinical presentation varied significantly between age groups; younger patients were more likely to present palpable cervical lymph nodes, while older patients frequently had solitary thyroid nodules. Family history and identifiable risk factors were similar across groups. However, older patients had higher rates of prior neoplasia and radiation exposure. Age also influenced surgical treatment and outcomes, including complications and recurrence rates. Conclusion: Our findings corroborate previous evidence on the predominance of papillary carcinoma and the association between radiation exposure and thyroid cancer. Younger patients demonstrated more aggressive tumor characteristics and higher recurrence rates, underscoring the need for age-specific management strategies. Early detection, comprehensive surgical intervention, and multidisciplinary follow-up are essential for achieving optimal outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201102&lng=en&tlng=enAdolescentsFollicular thyroid cancerThyroid cancerpapillaryPediatricsThyroid neoplasms |
| spellingShingle | Laura Leite-Almeida Rita Santos Silva Margarida Vicente-Ferreira Carla Costa Norberto Estevinho Cíntia Castro-Correia Sofia Ferreira Maria Bom-Sucesso Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients Archives of Endocrinology and Metabolism Adolescents Follicular thyroid cancer Thyroid cancer papillary Pediatrics Thyroid neoplasms |
| title | Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients |
| title_full | Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients |
| title_fullStr | Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients |
| title_full_unstemmed | Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients |
| title_short | Age-related characteristics in differentiated thyroid cancer: a 20-year single-center retrospective analysis in pediatric and adolescent patients |
| title_sort | age related characteristics in differentiated thyroid cancer a 20 year single center retrospective analysis in pediatric and adolescent patients |
| topic | Adolescents Follicular thyroid cancer Thyroid cancer papillary Pediatrics Thyroid neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000201102&lng=en&tlng=en |
| work_keys_str_mv | AT lauraleitealmeida agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT ritasantossilva agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT margaridavicenteferreira agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT carlacosta agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT norbertoestevinho agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT cintiacastrocorreia agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT sofiaferreira agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients AT mariabomsucesso agerelatedcharacteristicsindifferentiatedthyroidcancera20yearsinglecenterretrospectiveanalysisinpediatricandadolescentpatients |